Serotonin plays an important role in the etiology of depression. Serotonin is also crucial for
brain development. For instance, animal studies have demonstrated that early disruptions in …

This systematic review reports on moderating and mediating variables in the relationship
between childhood adversity and affective disorders. Embase, MEDLINE & PsycINFO were …

Family, twin, and epidemiologic studies have suggested that both genes and environment
are important risk factors for the development of major depressive disorder (MDD). In the …

To date, gene-environment (GxE) interaction studies in depression have been limited to
hypothesis-based candidate genes, since genome-wide (GWAS)-based GxE interaction …

Objective We examined children's risk and resilience following a natural disaster, evaluating
the role of stress, social support, and two genetic markers: the short allele of the serotonin …

With recent studies using genetic, epigenetic, and other molecular and neurochemical
approaches, a new era has begun in understanding pathophysiology of suicide. Emerging …

OBJECTIVE: First, we give an overview of child psychiatric research in the Generation R
Study, a population-based cohort from fetal life forward. Second, we examine within …

Background Prenatal maternal stress is increasingly recognized as a risk factor for offspring
mental health challenges. DNA methylation may be a mechanism, but few studies directly …

Background Severe mental illness (SMI), including schizophrenia, bipolar disorder and
severe depression, is responsible for a substantial proportion of disability in the population …

Background Recent studies have examined the role that the serotonergic system plays in
moderating the association between adverse childhood experiences (ACEs) and depressive …