Major depression and anxiety are highly prevalent and involve chronic dysregulation of
serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic …

While many studies focus on the association between early life adversity and the later risk
for psychopathology, few simultaneously explore diverse forms of environmental adversity …

The starting point for the study of adverse experiences is that some have enduring
consequences that continue after the period of exposure to the adversity. That raises four …

Response to antidepressants is interindividually variable. It has been suggested that this
variability is a direct consequence of etiological heterogeneity. Therefore, the same genes …

A principal weakness of evidence‐based psychiatry is that it does not account for the
individual variability in therapeutic response among individuals with the same diagnosis …

Early-life stress (ELS) is associated with substantially increased lifetime risk for recurrent
psychological problems, with evidence indicating that dysregulation of the physiological …

A decade of research has demonstrated the explanatory potential of interplay between
genetic variants and environmental factors in the development of common mental disorders …

Atrophy of neurons and gross structural alterations of limbic brain regions, including the
prefrontal cortex (PFC) and hippocampus, have been reported in brain imaging and …

Det er en prioritert samfunnsoppgave å beskytte barn mot vold og overgrep. Likevel tyder
tidligere undersøkelser på at altfor mange barn og unge opplever vold, seksuelle overgrep …

Background While cytokines have been implicated in the pathophysiology of depression in
adults, the potential role in younger age groups such as adolescents is less clear. This …