Traditionally, depressive disorders have been viewed as acute and time-limited. However, in
recent decades, depression has been reconceptualized as a highly recurrent or chronic and …

BACKGROUND: There is ongoing interest in the possible interaction of the serotonin-
transporter-linked polymorphic region (5-HTTLPR) with environmental factors in determining …

Depression is one of the major global health challenges and a leading contributor of health
related disability and costs. Depression is a heterogeneous disorder and current methods …

Objective. To summarize current concepts on neuroendocrine and genetic principles
underlying stress-related depression and to discuss the challenges of personalized …

Objective: This study investigated a potential interaction between the triallelic polymorphism
of the serotonin transporter gene (SLC6A4) promoter and the experience of childhood …

Research findings indicate that dysthymic disorder is a heterogeneous diagnosis
encompassing many different depressive (and anxiety or personality weighted) conditions …

Major depressive disorder (MDD) is responsible for an increasing individual and global
health burden. Extensive research on the genetic disposition to develop MDD and to predict …

Background Chronic exposure to job-related stress can lead to depression and BDNF
polymorphism may play an important role in this process. The role of the stress× BDNF …

Environmental exposures during the perinatal period are known to have a long-term effect
on adult physical and mental health. One such influential environmental exposure is the time …

Objective: Replication of scientific findings is a major challenge in biomedical research. In
psychiatry, the identification of measured gene-environment interactions (G× E) has …