Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …
[HTML][HTML] Multi-omics approaches to disease
High-throughput technologies have revolutionized medical research. The advent of
genotyping arrays enabled large-scale genome-wide association studies and methods for …
genotyping arrays enabled large-scale genome-wide association studies and methods for …
[HTML][HTML] Climate change impacts on food security-focus on perennial cropping systems and nutritional value
CP Leisner - Plant Science, 2020 - Elsevier
Anthropogenic increases in fossil fuel emissions have been a primary driver of increased
concentrations of atmospheric carbon dioxide ([CO 2]) and other greenhouse gases …
concentrations of atmospheric carbon dioxide ([CO 2]) and other greenhouse gases …
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
[HTML][HTML] The precision-recall plot is more informative than the ROC plot when evaluating binary classifiers on imbalanced datasets
T Saito, M Rehmsmeier - PloS one, 2015 - journals.plos.org
Binary classifiers are routinely evaluated with performance measures such as sensitivity and
specificity, and performance is frequently illustrated with Receiver Operating Characteristics …
specificity, and performance is frequently illustrated with Receiver Operating Characteristics …
Deconstructing the sources of genotype-phenotype associations in humans
Efforts to link variation in the human genome to phenotypes have progressed at a
tremendous pace in recent decades. Most human traits have been shown to be affected by a …
tremendous pace in recent decades. Most human traits have been shown to be affected by a …
Multi-omics integration in biomedical research–A metabolomics-centric review
Recent advances in high-throughput technologies have enabled the profiling of multiple
layers of a biological system, including DNA sequence data (genomics), RNA expression …
layers of a biological system, including DNA sequence data (genomics), RNA expression …
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
J Bentham, DL Morris, DS Cunninghame Graham… - Nature …, 2015 - nature.com
Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease
characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous …
characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous …
[HTML][HTML] A new approach for efficient genotype imputation using information from relatives
M Sargolzaei, JP Chesnais… - BMC …, 2014 - bmcgenomics.biomedcentral.com
Genotype imputation can help reduce genotyping costs particularly for implementation of
genomic selection. In applications entailing large populations, recovering the genotypes of …
genomic selection. In applications entailing large populations, recovering the genotypes of …
[HTML][HTML] The advantages and limitations of trait analysis with GWAS: a review
Over the last 10 years, high-density SNP arrays and DNA re-sequencing have illuminated
the majority of the genotypic space for a number of organisms, including humans, maize …
the majority of the genotypic space for a number of organisms, including humans, maize …