Learnings from these examples should facilitate other researchers to consider incorporating
research on omics technologies into their work to advance the field and our understanding …

Context Both type 1 diabetes (T1D) and type 2 diabetes (T2D) have significant genetic
contributions to risk and understanding their overlap can offer clinical insight. Objective We …

Type 2 diabetes (T2D) prevalence in adults at a younger age has increased but the disease
status may go unnoticed. This study aimed to determine whether the onset age and …

Abstract Background Heterozygous familial hypercholesterolemia (HeFH) is a monogenic
disorder characterized by increased circulating low-density lipoprotein cholesterol and …

Introduction: Genetic factors impact alcohol consumption and use disorder (AUD), with large-
scale genome-wide association studies (GWAS) identifying numerous associated variants …

Background The genetic basis of type 2 diabetes (T2D) is under-investigated in the Middle
East, despite the rapidly growing disease prevalence. We aimed to define the genetic …

Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because
it increases overdiagnosis and overtreatment of clinically insignificant tumors. We …

Cardiovascular diseases (CVDs) are complex in their aetiology, arising due to a
combination of genetics, lifestyle and environmental factors. By nature of this complexity …

Background and Objectives Nearly all genetic analyses of Parkinson disease (PD) have
been in populations of European ancestry. We sought to test the ability of a machine …

African Americans (AAs) have been underrepresented in polygenic risk score (PRS) studies.
Herein, we integrated genome-wide data from multiple observational studies on type 2 …