Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies

T Inoue, Y Yamamoto, K Sato, Y Okemoto-Nakamura… - Iscience, 2024 - cell.com
A current challenge is the emergence of SARS-CoV-2 variants, such as BQ. 1.1 and XBB.
1.5, that can evade immune defenses, thereby limiting antibody drug effectiveness …

[HTML][HTML] Broad SARS-CoV-2 neutralization by monoclonal and bispecific antibodies derived from a Gamma-infected individual

D Guerra, T Beaumont, L Radić, G Kerster… - Iscience, 2023 - cell.com
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has remained a medical threat due to the evolution of multiple variants that acquire …

[HTML][HTML] A dual-targeting approach using a human bispecific antibody against the receptor-binding domain of the Middle East Respiratory Syndrome Coronavirus

JH Lee, JW Kim, HE Lee, JY Song, AH Cho, JH Hwang… - Virus Research, 2024 - Elsevier
The emergence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has
posed a significant global health concern due to its severe respiratory illness and high …