Minor electrostatic changes robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles

BB Motsa, T Sharma, MD Cioffi, PP Chapagain… - Journal of Biological …, 2024 - ASBMB
Ebola virus (EBOV) is a filamentous negative-sense RNA virus, which causes severe
hemorrhagic fever. There are limited vaccines or therapeutics for prevention and treatment …

[HTML][HTML] Minor changes in electrostatics robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles

BB Motsa, T Sharma, PP Chapagain, RV Stahelin - bioRxiv, 2024 - ncbi.nlm.nih.gov
Ebola virus (EBOV) is a filamentous negative-sense RNA virus which causes severe
hemorrhagic fever. There are limited vaccines or therapeutics for prevention and treatment …

A broadly-neutralizing antibody against Ebolavirus glycoprotein that potentiates the breadth and neutralization potency of other antibodies

FR Donnellan, V Rayaprolu, P Rijal, V O'Dowd… - bioRxiv, 2024 - biorxiv.org
Ebolavirus disease (EVD) is caused by multiple species of Ebolavirus. Monoclonal
antibodies (mAbs) against the virus glycoprotein (GP) are the only class of therapeutic …

The role of conventional dendritic cell subsets in T-cell activation in Ebola virus infection

LR Niemetz - 2024 - ediss.sub.uni-hamburg.de
Severe Ebola virus disease (EVD) is characterized by excess, dysregulated T cell activation
and high levels of inflammation. In conflict with these clinical observations, in vitro studies …

Гуманизированные антитела. Современные разработки и перспективы создания медицинских средств биологической защиты

АС Горшков, ДВ Печенкин, АВ Кузнецовский… - Вестник войск РХБ …, 2024 - nbsprot.ru
Аннотация Пассивная иммунизация–вариант иммунизации, при котором в организм
вводятся антитела в достаточном для оказания лечебного эффекта количестве.«Окном …

[PDF][PDF] Reforming the research and development ecosystem for neglected diseases, emerging infectious diseases, and maternal health

M Schäferhoff, G Yamey, O Ogbuoji, A Fawole… - centerforpolicyimpact.org
Acknowledgements: We thank all key informants for generously sharing their expertise and
relevant data. We also thank Luca Pusceddu from Open Consultants and Jane Claire …