[HTML][HTML] Genetics of cardiovascular disease: How far are we from personalized CVD risk prediction and management?
M Vrablik, D Dlouha, V Todorovova, D Stefler… - International journal of …, 2021 - mdpi.com
Despite the rapid progress in diagnosis and treatment of cardiovascular disease (CVD), this
disease remains a major cause of mortality and morbidity. Recent progress over the last two …
disease remains a major cause of mortality and morbidity. Recent progress over the last two …
Addressing the challenge of biomedical data inequality: An artificial intelligence perspective
Artificial intelligence (AI) and other data-driven technologies hold great promise to transform
healthcare and confer the predictive power essential to precision medicine. However, the …
healthcare and confer the predictive power essential to precision medicine. However, the …
Risk of early-onset depression associated with polygenic liability, parental psychiatric history, and socioeconomic status
Importance Combining information on polygenic risk scores (PRSs) with other known risk
factors could potentially improve the identification of risk of depression in the general …
factors could potentially improve the identification of risk of depression in the general …
[PDF][PDF] Combined utility of 25 disease and risk factor polygenic risk scores for stratifying risk of all-cause mortality
While genome-wide association studies have identified susceptibility variants for numerous
traits, their combined utility for predicting broad measures of health, such as mortality …
traits, their combined utility for predicting broad measures of health, such as mortality …
Utility of polygenic embryo screening for disease depends on the selection strategy
Polygenic risk scores (PRSs) have been offered since 2019 to screen in vitro fertilization
embryos for genetic liability to adult diseases, despite a lack of comprehensive modeling of …
embryos for genetic liability to adult diseases, despite a lack of comprehensive modeling of …
[HTML][HTML] Polyneuro risk scores capture widely distributed connectivity patterns of cognition
Resting-state functional connectivity (RSFC) is a powerful tool for characterizing brain
changes, but it has yet to reliably predict higher-order cognition. This may be attributed to …
changes, but it has yet to reliably predict higher-order cognition. This may be attributed to …
[HTML][HTML] Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog
AD Hingorani, J Gratton, C Finan, AF Schmidt… - BMJ …, 2023 - ncbi.nlm.nih.gov
Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary
analysis of data in the Polygenic Score Catalog - PMC Back to Top Skip to main content NIH …
analysis of data in the Polygenic Score Catalog - PMC Back to Top Skip to main content NIH …
[HTML][HTML] Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups
N Kurniansyah, MO Goodman, AT Khan, J Wang… - Nature …, 2023 - nature.com
We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood
pressure (BP) phenotypes in diverse population groups. We compare “clumping-and …
pressure (BP) phenotypes in diverse population groups. We compare “clumping-and …
[HTML][HTML] An ensemble penalized regression method for multi-ancestry polygenic risk prediction
Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve
the prediction of complex traits and diseases. However, most existing PRS are primarily …
the prediction of complex traits and diseases. However, most existing PRS are primarily …
[HTML][HTML] The genetic basis of hypertriglyceridemia
GD Carrasquilla, MR Christiansen… - Current atherosclerosis …, 2021 - Springer
Abstract Purpose of Review Hypertriglyceridemia is a common dyslipidemia associated with
an increased risk of cardiovascular disease and pancreatitis. Severe hypertriglyceridemia …
an increased risk of cardiovascular disease and pancreatitis. Severe hypertriglyceridemia …