As the histology, physiology, and pathophysiology of eyes and kidneys show substantial
overlap, it has been suggested that eye and kidney diseases, such as glaucoma and chronic …

Polygenic risk scores represent a method of aggregating an individual's genetic information,
weighted by associations between genetic variants and disease outcomes identified from …

Understanding the noncoding part of the genome, which encodes gene regulation, is
necessary to identify genetic mechanisms of disease and translate findings from genome …

Background & Aims Gastrointestinal cancer risk is influenced by the presence of metabolic
syndrome (MetS). However, previous epidemiologic studies lacked full serological …

Polygenic risk scores are becoming increasingly predictive of complex traits, but their
suboptimal performance in non-European ancestry populations raises questions about their …

Background Many families with clinical early-onset Alzheimer's disease (EOAD) remain
genetically unexplained. A combination of genetic factors is not standardly investigated. In …

One of the basic challenges to the successful management of obesity is the failure to
consider obesity as a disease or chronic disease and as a challenge to modern medicine.• …

Polygenic scores (PGS) are commonly evaluated in terms of their predictive accuracy at the
population level by the proportion of phenotypic variance they explain. To be useful for …

'The Apportionment of Human Diversity'stands as a noteworthy intervention, both for the field
of human population genetics as well as in the annals of public communication of science …

The fields of human genetics and genomics have generated considerable knowledge about
the mechanistic basis of many diseases. Genomic approaches to diagnosis, prognostication …