Early antibody lineage diversification and independent limb maturation lead to broad HIV-1 neutralization targeting the Env high-mannose patch
The high-mannose patch on HIV Env is a preferred target for broadly neutralizing antibodies
(bnAbs), but to date, no vaccination regimen has elicited bnAbs against this region. Here, we …
(bnAbs), but to date, no vaccination regimen has elicited bnAbs against this region. Here, we …
Strategies for a multi-stage neutralizing antibody-based HIV vaccine
Highlights•A neutralizing antibody-based vaccine is needed to curb the global HIV
pandemic.•Current vaccine approaches target unique features of bnAb precursors.• …
pandemic.•Current vaccine approaches target unique features of bnAb precursors.• …
Insights into the structural basis of antibody affinity maturation from next-generation sequencing
AK Mishra, RA Mariuzza - Frontiers in immunology, 2018 - frontiersin.org
Affinity maturation is the process whereby the immune system generates antibodies of
higher affinities during a response to antigen. It is unique in being the only evolutionary …
higher affinities during a response to antigen. It is unique in being the only evolutionary …
Broadly neutralizing antibodies targeting HIV: Progress and challenges
Anti-HIV broadly neutralizing antibodies (bNAbs) offer a novel approach to treating,
preventing, or curing HIV. Pre-clinical models and clinical trials involving the passive transfer …
preventing, or curing HIV. Pre-clinical models and clinical trials involving the passive transfer …
Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies
V Ovchinnikov, JE Louveau, JP Barton, M Karplus… - Elife, 2018 - elifesciences.org
Eliciting antibodies that are cross reactive with surface proteins of diverse strains of highly
mutable pathogens (eg, HIV, influenza) could be key for developing effective universal …
mutable pathogens (eg, HIV, influenza) could be key for developing effective universal …
Structure of super-potent antibody CAP256-VRC26. 25 in complex with HIV-1 envelope reveals a combined mode of trimer-apex recognition
Antibodies targeting the V1V2 apex of the HIV-1 envelope (Env) trimer comprise one of the
most commonly elicited categories of broadly neutralizing antibodies. Structures of these …
most commonly elicited categories of broadly neutralizing antibodies. Structures of these …
HIV envelope glycoform heterogeneity and localized diversity govern the initiation and maturation of a V2 apex broadly neutralizing antibody lineage
Understanding how broadly neutralizing antibodies (bnAbs) to HIV envelope (Env) develop
during natural infection can help guide the rational design of an HIV vaccine. Here, we …
during natural infection can help guide the rational design of an HIV vaccine. Here, we …
cAb-Rep: a database of curated antibody repertoires for exploring antibody diversity and predicting antibody prevalence
The diversity of B cell receptors provides a basis for recognizing numerous pathogens.
Antibody repertoire sequencing has revealed relationships between B cell receptor …
Antibody repertoire sequencing has revealed relationships between B cell receptor …
HIV-1 envelope trimer design and immunization strategies to induce broadly neutralizing antibodies
SW de Taeye, JP Moore, RW Sanders - Trends in immunology, 2016 - cell.com
The identification of multiple broadly neutralizing antibodies (bNAbs) against the HIV-1
envelope glycoprotein (Env) trimer has facilitated its structural characterization and guided …
envelope glycoprotein (Env) trimer has facilitated its structural characterization and guided …
Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth
RS Roark, H Li, WB Williams, H Chug, RD Mason… - Science, 2021 - science.org
INTRODUCTION It is widely believed that the development of an effective neutralizing
antibody–based HIV-1 vaccine will require consistent activation of multiple germline …
antibody–based HIV-1 vaccine will require consistent activation of multiple germline …