The achievements of vaccine research and development bring a hope to our societies that
we may cope with the COVID‐19 pandemic. There are two aspects that should be …

Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and
impose a heavy economic burden on affected countries. These diseases predominantly …

The dry season is a major challenge for Plasmodium falciparum parasites in many malaria
endemic regions, where water availability limits mosquito vectors to only part of the year …

Malaria is a mosquito-borne disease caused by protozoan parasites of the genus
Plasmodium. Despite significant declines in malaria-attributable morbidity and mortality over …

The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

Malaria is a vector-borne disease of global importance, with the vast majority of its life-
threatening cases caused by infection with Plasmodium falciparum parasites. Repeated …

In 1967, pioneering work by Ruth Nussenzweig demonstrated for the first time that irradiated
sporozoites of the rodent malaria parasite Plasmodium berghei protected mice against a …

While prevention is a bedrock of public health, innovative therapeutics are needed to
complement the armamentarium of interventions required to achieve disease control and …

Background Modelling and simulation are being increasingly utilized to support the
discovery and development of new anti-malarial drugs. These approaches require reliable …

Highlights•The antimalarial pipeline has been enriched with new molecules and
targets.•The antimalarial target compound and product profiles have been redefined.•In …