Controlled human malaria infection (CHMI) provides a highly informative means to
investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of …

Tuberculosis kills more people than any other pathogen and the need for a universally
effective vaccine has never been greater. An effective vaccine will be a key tool in achieving …

Malaria is spread by the transmission of sexual stage parasites, called gametocytes.
However, with Plasmodium falciparum, gametocytes can only be detected in peripheral …

Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and
host in shaping disease severity remains unclear. We explored the interaction between …

Background Artemisinin resistance is threatening malaria control. We aimed to develop and
test a human model of artemisinin-resistant (ART-R) Plasmodium falciparum to evaluate the …

Malaria, caused by Plasmodium species, remains a major global health concern, causing
millions of deaths annually. While the introduction of the RTS, S vaccine has shown promise …

The increasing recent interest in human challenge studies or controlled human infection
model studies for accelerating vaccine development has been driven by the recognition of …

Whole-sporozoite (WSp) malaria vaccines induce protective immune responses in animal
malaria models and in humans. A recent clinical trial with a WSp vaccine comprising …

Infection by malaria parasites (Plasmodium spp.) remains one of the leading causes of
morbidity and mortality, especially in tropical regions of the world. Despite the availability of …

Background The continuing morbidity and mortality associated with infection with malaria
parasites highlights the urgent need for a vaccine. The efficacy of sub-unit vaccines tested in …