Abstract Group A Streptococcus (GAS) is a highly-adapted and human-restricted pathogen
responsible for a high global burden of disease across a diverse clinical spectrum. Vaccine …

Introduction: An effective vaccine against malaria forms a global health priority. Both
naturally acquired immunity and sterile protection induced by irradiated sporozoite …

Although viruses and bacteria have been known as agents of diseases since 1546, 250
years went by until the first vaccines against these pathogens were developed (1796 and …

Background We assessed the impact of exposure to Plasmodium falciparum on parasite
kinetics, clinical symptoms, and functional immunity after controlled human malaria infection …

Introduction: The challenge to eradicate malaria is an enormous task that will not be
achieved by current control measures, thus an efficacious and long-lasting malaria vaccine …

The Zika virus (ZIKV) was first isolated from a rhesus macaque in the Zika forest of Uganda
in 1947. Isolated cases were reported until 2007, when the first major outbreaks of Zika …

Introduction: Malaria challenge models, where healthy human volunteers are intentionally
infected with Plasmodium species parasites under controlled conditions, can be undertaken …

COVID-19 is a very complex pandemic. It has affected individuals, different countries and
regions of the world equally in some senses and differently in other senses. While sub …

The availability of an effective and appropriately implemented malaria vaccine would form a
crucial cornerstone of public health efforts to fight this disease. Despite many decades of …

Anti-circumsporozoite antibody titres have been established as an essential indicator for
evaluating the immunogenicity and protective capacity of the RTS, S/AS01 malaria vaccine …