Endothelial activation and microvascular dysfunction are key pathogenic processes in
severe malaria. We evaluated the early role of these processes in experimentally induced …

Four healthy volunteers were infected with 50 Necator americanus infective larvae (L3) in a
controlled human hookworm infection trial and followed for 52 weeks. The kinetics of fecal …

Malaria is an infectious disease which disproportionately effects children and pregnant
women. These vulnerable populations are often excluded from clinical trials resulting in one …

Our understanding of the human immune response to malaria remains incomplete. Clinical
trials using whole-sporozoite-based vaccination approaches such as the Sanaria PfSPZ …

Abstract Background The transcriptome of Plasmodium falciparum clinical isolates varies
according to strain, mosquito bites, disease severity and clinical history. Therefore, it …

Controlled human malaria infection (CHMI) is a powerful tool to evaluate the efficacy of
malaria vaccines and pharmacologics. Investigators at the University of Maryland, Baltimore …

Vaccine efficacy and prophylactic treatment of infections are tested best when the
vaccinated or treated individual is challenged through deliberate infection with the …

Background Transcriptional profiling of the human immune response to malaria has been
used to identify diagnostic markers, understand the pathogenicity of severe disease and …

Parasites of the phylum Apicomplexa are the causative agents of important diseases such
as malaria, toxoplasmosis or cryptosporidiosis in humans, and babesiosis and coccidiosis in …

Chimeric rodent malaria parasites with the endogenous circumsporozoite protein (csp) gene
replaced with csp from the human parasites Plasmodium falciparum (Pf) and P. vivax (Pv) …