Background Rodent malaria parasites where the gene encoding circumsporozoite protein
(CSP) has been replaced with csp genes from the human malaria parasites, Plasmodium …

Controlled human infection studies have contributed significantly to the understanding of
pathogeneses and treatment of infectious diseases. In malaria, deliberately infecting …

Malaria has become a widespread disease and one of the leading causes of many deaths
worldwide. Malaria is a blood disease brought on by Plasmodium parasites, which are …

Introduction Malaria remains a devastating infectious disease with hundreds of thousands of
casualties each year. Antimalarial drug resistance has been a threat to malaria control and …

Introduction: As the quest for an effective blood stage malaria vaccine continues, there is
increasing reliance on the use of controlled human malaria infections (CHMI) in non …

The interaction of malaria parasites with their human host is extensively studied, yet only few
studies reported how P. falciparum infection affects urinary metabolite profiles and how this …

Background New anti-malarial therapeutics are required to counter the threat of increasing
drug resistance. Malaria volunteer infection studies (VIS), particularly the induced blood …

Human experimentation by deliberate infection with malarial parasites seems unethical yet
has a long history in infectious disease research. After rigorous screening, volunteers are …

Objective To quantitatively investigate the motivations, decision-making and experience of
participants in controlled human infection (CHI) studies. Design Cross-sectional descriptive …

The use of malaria rapid diagnostic tests (RDTs) as a source for nucleic acids that can be
analyzed via nucleic acid amplification techniques has several advantages, including …