Human experimentation by deliberate infection with malarial parasites seems unethical yet
has a long history in infectious disease research. After rigorous screening, volunteers are …

Objective To quantitatively investigate the motivations, decision-making and experience of
participants in controlled human infection (CHI) studies. Design Cross-sectional descriptive …

The use of malaria rapid diagnostic tests (RDTs) as a source for nucleic acids that can be
analyzed via nucleic acid amplification techniques has several advantages, including …

Background Streptococcus pyogenes causes a profound global burden of morbidity and
mortality across its diverse clinical spectrum. To support a new controlled human infection …

Introduction: Despite decades of research into the development of a vaccine to combat the
malaria parasite, a highly efficacious malaria vaccine is not yet available. Different whole …

Immunity to severe malaria is acquired quickly, operates independently of pathogen load
and represents a highly effective form of disease tolerance. The mechanism that underpins …

Tuberculosis (TB) is currently responsible for more deaths per annum than any other
pathogen (1). Despite modest gains in control in recent years, the rate of progress is too …

Background It is unclear if malaria causes deranged liver enzymes. This has implications
both in clinical practice and in research, particularly for antimalarial drug development …

Background Sensitive molecular assays, such as quantitative reverse-transcription
polymerase chain reaction (qRT-PCR) of Plasmodium 18S ribosomal RNA (rRNA), are …

Plain language summary This paper describes a provisional clinical protocol for the pilot
human challenge model of Mycobacterium ulcerans infection, which causes the skin …