Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated
protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are …

The p53-related genes p63 and p73 exhibit significant structural homology to p53; however,
they do not function as classical tumor suppressors and are rarely mutated in human …

Notch signaling promotes commitment of keratinocytes to differentiation and suppresses
tumorigenesis. p63, a p53 family member, has been implicated in establishment of the …

We demonstrate that ΔNp63α is an essential survival factor in head and neck squamous cell
carcinoma (HNSCC) through its ability to suppress p73-dependent apoptosis. Inhibition of …

Purpose: To identify molecular markers of pathologic response to neoadjuvant
paclitaxel/radiation treatment, protein and gene expression profiling were done on …

Abstract p63, a homologue of the tumor suppressor p53, is critical for the development and
maintenance of squamous epithelia. p63 is specifically expressed in the basal layers of …

Background One major defining characteristic of the basal keratinocytes of the stratified
epithelium is the expression of the keratin genes K5 and K14. The temporal and spatial …

Abstract p63 belongs to a family of transcription factors, which, while demonstrating striking
conservation of functional domains, regulate distinct biological functions. Its principal role is …

Molecular links between apoptosis, tumorigenesis and drug resistance provide starting
points for new therapeutic approaches and for a targeted cancer therapy. The discovery of …

Squamous cell carcinoma (SCC) is a treatment‐refractory tumour which arises from the
epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin …