Atomic resolution structures of CTX-M β-lactamases: extended spectrum activities from increased mobility and decreased stability

Y Chen, J Delmas, J Sirot, B Shoichet… - Journal of molecular …, 2005 - Elsevier
Extended spectrum β-lactamases (ESBLs) confer bacterial resistance to third-generation
cephalosporins, such as cefotaxime and ceftazidime, increasing hospital mortality rates …

[HTML][HTML] Achromobacter xylosoxidans bacteremia: clinical and microbiological features in a 10-year case series

EP Barragán, JS Pérez, L Corbella… - Revista Española de …, 2018 - ncbi.nlm.nih.gov
Achromobacter xylosoxidans bacteremia: clinical and microbiological features in a 10-year
case series - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

An update on cefepime and its future role in combination with novel β-lactamase inhibitors for MDR Enterobacterales and Pseudomonas aeruginosa

B Isler, P Harris, AG Stewart… - Journal of Antimicrobial …, 2021 - academic.oup.com
Cefepime, a wide-spectrum β-lactam antibiotic, has been in use for the treatment of serious
bacterial infections for almost 25 years. Since its clinical development, there has been a …

Pathogen-specific early mortality in very low birth weight infants with late-onset sepsis: a national survey

IR Makhoul, P Sujov, T Smolkin, A Lusky… - Clinical Infectious …, 2005 - academic.oup.com
Background. Late-onset sepsis (LOS) is an important cause of mortality among very low birth
weight (VLBW) infants, and deaths occurring within 3 days after the onset of sepsis can …

[HTML][HTML] Impact of empirical treatment in extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. bacteremia. A multicentric cohort study

G Peralta, M Lamelo, P Álvarez-García… - BMC infectious …, 2012 - Springer
Background The objective of this study is to analyze the factors that are associated with the
adequacy of empirical antibiotic therapy and its impact in mortality in a large cohort of …

Contact Precautions for Preventing Nosocomial Transmission of Extended-Spectrum β Lactamase–Producing Escherichia coli: A Point/Counterpoint Review

S Tschudin-Sutter, JC Lucet, NT Mutters… - Clinical infectious …, 2017 - academic.oup.com
Contact precautions have been recommended for hospitalized patients colonized or infected
with extended-spectrum β-lactamase–producing Escherichia coli (ESBL-EC). Despite such …

Initial Use of Echinocandins Does Not Negatively Influence Outcome in Candida parapsilosis Bloodstream Infection: A Propensity Score Analysis

M Fernández-Ruiz, JM Aguado… - Clinical infectious …, 2014 - academic.oup.com
Initial Use of Echinocandins Does Not Negatively Influence Outcome in Candida
parapsilosis Bloodstream Infection: A Propensity Score Analysis | Clinical Infectious …

Impact of cefepime therapy on mortality among patients with bloodstream infections caused by extended-spectrum-β-lactamase-producing Klebsiella pneumoniae and …

T Chopra, D Marchaim, J Veltman… - Antimicrobial agents …, 2012 - Am Soc Microbiol
ABSTRACT Extended-spectrum-β-lactamase (ESBL)-producing pathogens are associated
with extensive morbidity and mortality and rising health care costs. Scant data exist on the …

Antimicrobial resistance in the intensive care unit: mechanisms, epidemiology, and management of specific resistant pathogens

HS Fraimow, C Tsigrelis - Critical care clinics, 2011 - criticalcare.theclinics.com
Drug-resistant and multidrug-resistant (MDR) microbial pathogens have emerged as major
concerns both in and out of the hospital environment. Drug-resistant pathogens pose …

Increased risk for and mortality from invasive pneumococcal disease in HIV-exposed but uninfected infants aged< 1 year in South Africa, 2009–2013

C Von Mollendorf, A Von Gottberg… - Clinical Infectious …, 2015 - academic.oup.com
Background. High antenatal human immunodeficiency virus (HIV) seroprevalence rates (∼
30%) with low perinatal HIV transmission rates (2.5%), due to HIV prevention of mother-to …