Cell biology of activated protein C
K Shahzad, S Kohli, B Isermann - Current opinion in hematology, 2019 - journals.lww.com
Cell biology of activated protein C : Current Opinion in Hematology Cell biology of activated
protein C : Current Opinion in Hematology Log in or Register Subscribe to journalSubscribe …
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[HTML][HTML] Targeting coagulation activation in severe COVID-19 pneumonia: lessons from bacterial pneumonia and sepsis
RJ José, A Williams, A Manuel… - European …, 2020 - Eur Respiratory Soc
Novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-
coronavirus-2 (SARS-CoV-2), has rapidly spread throughout the world, resulting in a …
coronavirus-2 (SARS-CoV-2), has rapidly spread throughout the world, resulting in a …
The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling
EM Gleeson, JS O'Donnell, RJS Preston - Cellular and Molecular Life …, 2012 - Springer
Increasing evidence links blood coagulation proteins with the regulation of acute and
chronic inflammatory disease. Of particular interest are vitamin K-dependent proteases …
chronic inflammatory disease. Of particular interest are vitamin K-dependent proteases …
[HTML][HTML] Coagulation factor Xa cleaves protease‐activated receptor‐1 and mediates signaling dependent on binding to the endothelial protein C receptor
RA Schuepbach, M Riewald - Journal of Thrombosis and Haemostasis, 2010 - Elsevier
Background and objective: Coagulation is intrinsically tied to inflammation, and both
proinflammatory and anti‐inflammatory responses are modulated by coagulation protease …
proinflammatory and anti‐inflammatory responses are modulated by coagulation protease …
FVIIa (factor VIIa) induces biased cytoprotective signaling in mice through the cleavage of PAR (protease-activated receptor)-1 at canonical Arg41 (Arginine41) site
V Kondreddy, UR Pendurthi, X Xu… - … and Vascular Biology, 2020 - Am Heart Assoc
Objective: Recent studies showed that FVIIa (factor VIIa), upon binding to EPCR (endothelial
cell protein C receptor), elicits endothelial barrier stabilization and anti-inflammatory effects …
cell protein C receptor), elicits endothelial barrier stabilization and anti-inflammatory effects …
Decitabine and 5-azacitidine both alleviate LPS induced ARDS through anti-inflammatory/antioxidant activity and protection of glycocalyx and inhibition of MAPK …
X Huang, G Kong, Y Li, W Zhu, H Xu, X Zhang… - Biomedicine & …, 2016 - Elsevier
Abstract Decitabine (5-aza-2′-deoxycytidine, DAC) and 5-azacitidine (Aza), an inhibitor of
DNA methyltransferases, possess a wide range of anti-metabolic and anti-cancer activities …
DNA methyltransferases, possess a wide range of anti-metabolic and anti-cancer activities …
Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats
Q Yuan, Y Jiang, T Ma, Q Fang, L Pan - Journal of Inflammation, 2014 - Springer
Background Sepsis causes neutrophil sequestration in the lung which leads to acute lung
injury (ALI). Radix Ginseng (RG), a traditional herb used as herbal remedy in eastern Asia …
injury (ALI). Radix Ginseng (RG), a traditional herb used as herbal remedy in eastern Asia …
Apolipoprotein E receptor 2 mediates activated protein C–induced endothelial AKT activation and endothelial barrier stabilization
RK Sinha, XV Yang, JA Fernández, X Xu… - … , and vascular biology, 2016 - Am Heart Assoc
Objective—Activated protein C (APC), a plasma serine protease, initiates cell signaling that
protects endothelial cells from apoptosis and endothelial barrier disruption. Apolipoprotein E …
protects endothelial cells from apoptosis and endothelial barrier disruption. Apolipoprotein E …
Barrier enhancing signals in pulmonary edema
KG Birukov, N Zebda… - Comprehensive Physiology, 2013 - Wiley Online Library
Increased endothelial permeability and reduction of alveolar liquid clearance capacity are
two leading pathogenic mechanisms of pulmonary edema, which is a major complication of …
two leading pathogenic mechanisms of pulmonary edema, which is a major complication of …
Activated protein C attenuates experimental autoimmune encephalomyelitis progression by enhancing vascular integrity and suppressing microglial activation
Background Activated protein C (APC), a serine protease with antithrombotic effects,
protects in animal models of ischemic stroke by suppressing inflammation and enhancing …
protects in animal models of ischemic stroke by suppressing inflammation and enhancing …