Glaucoma is a complex multifactorial eye disease manifesting in retinal ganglion cell (RGC)
death and optic nerve degeneration, ultimately causing irreversible vision loss. Research in …

The retina, as part of the central nervous system is an ideal model to study the response of
neurons to injury and disease and to test new treatments. During the last decade is …

Intravitreal delivery of brain-derived neurotrophic factor (BDNF) by injection of recombinant
protein or by gene therapy can alleviate retinal ganglion cell (RGC) loss after optic nerve …

How many RBPMS+ retinal ganglion cells (RGCs) does a standard C57BL/6 laboratory
mouse have on average and is this number substrain-or sex-dependent? Do RGCs of …

Background Advanced therapies using adult mesenchymal stromal cells (MSCs) for
neurodegenerative diseases are not effectively translated into the clinic. The cross talk …

We analyze the 7, 8-dihydroxyflavone (DHF)/TrkB signaling activation of two main
intracellular pathways, mitogen-activated protein kinase (MAPK)/ERK and …

Optic neuropathies are characterized by degeneration of retinal ganglion cell axonal
projections to the brain, including acute conditions like optic nerve trauma and progressive …

Background: To analyze the course of microglial and macroglial activation in injured and
contralateral retinas after unilateral optic nerve crush (ONC). Methods: The left optic nerve of …

Inherited photoreceptor degenerations are not treatable diseases and a frequent cause of
blindness in working ages. In this study we investigate the safety, integration and possible …

Mesenchymal stromal cell (MSC) therapy to treat neurodegenerative diseases has not been
as successful as expected in some preclinical studies. Because preclinical research is so …