The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …

Mammalian cells respond to stress by activating mechanisms that support cellular functions
and hence maintain microenvironmental and organismal homeostasis. Intracellular …

Although the subcellular dynamics of RNA and proteins are key determinants of cell
homeostasis, their characterization is still challenging. Here we present an integrative …

Accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a salient attribute of
many human diseases including obesity, liver disorders, cancer, diabetes and …

In response to disturbed mitochondrial gene expression and protein synthesis, an adaptive
transcriptional response sharing a signature of the integrated stress response (ISR) is …

Maternal infection and inflammation during pregnancy are associated with
neurodevelopmental disorders in offspring, but little is understood about the molecular …

Cells respond to intrinsic and extrinsic stresses by reducing global protein synthesis and
activating gene programs necessary for survival. Here, we show that the integrated stress …

Shutoff of global protein synthesis is a conserved response to cellular stresses. This general
phenomenon is accompanied by the induction of distinct gene programs tailored to each …

Proteostasis collapse, the diminished ability to maintain protein homeostasis, has been
established as a hallmark of nematode aging. However, whether proteostasis collapse …

Cannabidiol (CBD), a phytochemical derived from Cannabis sativa L., has been
demonstrated to exhibit promising anti-tumor properties in multiple cancer types. However …