A major barrier to the impact of genomic diagnosis in patients with congenital malformations
is the lack of understanding regarding how sequence variants contribute to disease …

Ionizing radiation (IR) is a pivotal diagnostic and treatment modality, yet it is also a potent
genotoxic agent that causes genome instability and carcinogenesis. While modern cancer …

Abstract Protein arginine methyltransferase 5 (PRMT5) was discovered two decades ago.
The first decade focused on the biochemical characterization of PRMT5 as a regulator of …

Aims: Aberrant histone acetylation has been associated with malignancy and histone
deacetylase (HDAC) inhibitors are currently being investigated in numerous clinical trials …

In eukaryotes, transcriptional regulation is determined by dynamic and reversible chromatin
modifications, such as acetylation, methylation, phosphorylation, ubiquitination …

Epigenetic events like DNA methylation and histone modification can alter heritable
phenotypes. Zinc is required for the activity of various epigenetic enzymes, such as DNA …

Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic
driver mutations in combination with chemotherapy and radiotherapy as well as …

All-trans-retinoic acid (RA) is a vitamin A metabolite that plays major roles in regulating stem
cell differentiation and development. RA is the ligand of the retinoic acid receptor (RAR) …

Chemical stressors can induce epigenomic changes, ie, changes that are transferred to the
next generation, even when the stressor is removed. Literature on chemical induced …

Background Recent technological advances have allowed us to examine the human
genome in greater detail than ever before. This has opened the door to an improved …