Microsporins A and B: New histone deacetylase inhibitors from the marine-derived fungus Microsporum cf. gypseum and the solid-phase synthesis of microsporin A

W Gu, M Cueto, PR Jensen, W Fenical, RB Silverman - Tetrahedron, 2007 - Elsevier
Two new cyclic peptides, microsporins A and B (7 and 8), were isolated from culture extracts
of the marine-derived fungus Microsporum cf. gypseum obtained from a sample of the …

Role of histone modification in the occurrence and development of osteoporosis

P Sun, T Huang, C Huang, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis is a systemic degenerative bone disease characterized by low bone mass and
damage to bone microarchitecture, which increases bone fragility and susceptibility to …

Histone deacetylase functions and therapeutic implications for adult skeletal muscle metabolism

S Molinari, C Imbriano, V Moresi, A Renzini… - Frontiers in Molecular …, 2023 - frontiersin.org
Skeletal muscle is a highly adaptive organ that sustains continuous metabolic changes in
response to different functional demands. Healthy skeletal muscle can adjust fuel utilization …

The roles of retinoic acid and retinoic acid receptors in inducing epigenetic changes

A Urvalek, KB Laursen, LJ Gudas - … of Retinoic Acid Receptors I: Structure …, 2014 - Springer
Epigenetics is “the branch of biology which studies the causal interactions between genes
and their products which bring the phenotype into being” as defined by Conrad Waddington …

[HTML][HTML] Application of histone deacetylase inhibitors in renal interstitial fibrosis

L Nie, Y Liu, B Zhang, J Zhao - Kidney Diseases, 2020 - karger.com
Background: Renal interstitial fibrosis is characterized by the accumulation of extracellular
matrix proteins, which is a common feature of chronic kidney diseases. Summary: Increasing …

Circadian mechanism disruption is associated with dysregulation of inflammatory and immune responses: a systematic review

N Fatima, GK Sonkar, S Singh - Beni-Suef University Journal of Basic and …, 2022 - Springer
The circadian rhythms are regulated by the circadian clock which is under the control of
suprachiasmatic nucleus of hypothalamus. The central and peripheral clocks on different …

Histone deacetylase‑2: A potential regulator and therapeutic target in liver disease

YR Liu, JQ Wang, ZG Huang… - International …, 2021 - spandidos-publications.com
Histone acetyltransferases are responsible for histone acetylation, while histone
deacetylases (HDACs) counteract histone acetylation. An unbalanced dynamic between …

Molecular effects and retinopathy induced by hydroxychloroquine during SARS-CoV-2 therapy: Role of CYP450 isoforms and epigenetic modulations

A Paniri, MM Hosseini, A Rasoulinejad… - European journal of …, 2020 - Elsevier
Antimalaria drugs such as chloroquine (CQ) and hydroxychloroquine (HCQ) have been
administered to several inflammatory diseases including rheumatoid arthritis and systemic …

Absence of HDAC3 by matrix stiffness promotes chromatin remodeling and fibroblast activation in idiopathic pulmonary fibrosis

F Toscano-Marquez, Y Romero, M Espina-Ordoñez… - Cells, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease characterized by
progressive and irreversible lung scarring associated with persistent activation of fibroblasts …

Epigenetics: Perspectives and potential in aquaculture

S Roy, V Kumar, BK Behera, BK Das - Advances in fisheries …, 2022 - Springer
Epigenetics has attracted considerable attention recently and presents great opportunities in
the aquaculture sector. Epigenetics literally means 'above'or 'on top of'genetics and …