HDAC1 substrate profiling using proteomics-based substrate trapping

DA Nalawansha, Y Zhang, K Herath… - ACS chemical …, 2018 - ACS Publications
Histone deacetylase (HDAC) proteins are overexpressed in multiple diseases, including
cancer, and have emerged as anticancer drug targets. HDAC proteins regulate cellular …

MC1568 enhances histone acetylation during oocyte meiosis and improves development of somatic cell nuclear transfer embryos in pig

H Wang, W Cui, C Meng, J Zhang, Y Li… - Cellular …, 2018 - liebertpub.com
An increasing number of studies have revealed that histone deacetylase (HDAC) mediated
histone deacetylation is important for mammalian oocyte development. However …

Regulation of thermogenic adipocyte differentiation and adaptive thermogenesis through histone acetylation

BX Ong, R Brunmeir, Q Zhang, X Peng… - Frontiers in …, 2020 - frontiersin.org
Over the past decade, the increasing prevalence of obesity and its associated metabolic
disorders constitutes one of the most concerning healthcare issues for countries worldwide …

TIP60 is required for tumorigenesis in non‐small cell lung cancer

D Shibahara, N Akanuma, IS Kobayashi, E Heo… - Cancer …, 2023 - Wiley Online Library
Histone modifications play crucial roles in transcriptional activation, and aberrant epigenetic
changes are associated with oncogenesis. Lysine (K) acetyltransferases 5 (TIP60, also …

[HTML][HTML] Acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancer

X Wang, N Li, M Zheng, Y Yu, S Zhang - Translational Oncology, 2024 - Elsevier
Adipocytes are derived from pluripotent mesenchymal stem cells and can develop into
several cell types including adipocytes, myocytes, chondrocytes, and osteocytes. Adipocyte …

Targeted mass spectrometric strategy for global mapping of ubiquitination on proteins

S Mollah, IE Wertz, Q Phung, D Arnott… - … Journal Devoted to …, 2007 - Wiley Online Library
Post‐translational modifications of proteins including phosphorylation, glycosylation,
acetylation and ubiquitination facilitate the regulation of many cellular processes and …

Neurodevelopmental and other phenotypes recurrently associated with heterozygous BAZ2B loss‐of‐function variants

S Sewani, MS Azamian, BA Mendelsohn… - American Journal of …, 2024 - Wiley Online Library
The bromodomain adjacent to zinc finger 2B (BAZ2B) gene encodes a chromatin
remodeling protein that has been shown to perform a variety of regulatory functions. It has …

Counteracting the Ramifications of UVB Irradiation and Photoaging with Swietenia macrophylla King Seed

CK Mahendra, SAZ Abidin, TT Htar, LH Chuah… - Molecules, 2021 - mdpi.com
In this day and age, the expectation of cosmetic products to effectively slow down skin
photoaging is constantly increasing. However, the detrimental effects of UVB on the skin are …

Elevated histone acetylations in Müller cell contribute to inflammation: A novel inhibitory effect of minocycline

LL Wang, H Chen, K Huang, L Zheng - Glia, 2012 - Wiley Online Library
Inflammation plays important roles in the development of diabetic retinopathy (DR). How
Müller cells contribute to DR‐related inflammation remains unclear. We hypothesized that …

Case Report: Pulmonary sarcomatoid carcinoma complicating TP53 mutation treated successfully with Tislelizumab combined with Anlotinib—a case report

YF Li, XF Zhao, Y Tian, XY Xiao, CY Yan… - Frontiers in …, 2022 - frontiersin.org
Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung malignant tumor.
Conventional chemotherapy has a suboptimal effectiveness. PSC has the characteristics of …