Single-nucleus RNA sequencing of midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular …

S Puvogel, A Alsema, L Kracht, MJ Webster… - Molecular …, 2022 - nature.com
The midbrain is an extensively studied brain region in schizophrenia, in view of its reported
dopamine pathophysiology and neuroimmune changes associated with this disease …

It takes two to tango: Widening our understanding of the onset of schizophrenia from a neuro-angiogenic perspective

BS Casas, D Arancibia-Altamirano… - Frontiers in Cell and …, 2022 - frontiersin.org
Schizophrenia is a chronic debilitating mental disorder characterized by perturbations in
thinking, perception, and behavior, along with brain connectivity deficiencies …

Schizophrenia endothelial cells exhibit higher permeability and altered angiogenesis patterns in patient-derived organoids

I Stankovic, M Notaras, P Wolujewicz, T Lu… - Translational …, 2024 - nature.com
Schizophrenia (SCZ) is a complex neurodevelopmental disorder characterized by the
manifestation of psychiatric symptoms in early adulthood. While many research avenues into …

[HTML][HTML] Deep Retinal Layer Microvasculature Alterations in Schizophrenia

SI Fradkin, D Bannai, P Lizano, A Lai, C Crosta… - Biomarkers in …, 2024 - Elsevier
A subset of individuals with schizophrenia (SZ) are thought to have a microvascular
component to their illness with studies demonstrating alterations in retinal superficial, deep …

In the afterglow: Immune dysfunction in schizophrenia spectrum disorders

S Gangadin - 2024 - research.rug.nl
Recovering from schizophrenia spectrum disorders (SSD) is challenging, because current
treatments are sub-optimal. Motivated to find a cure, researchers study the immune system …

Neurodevelopment, brain vasculature and schizophrenia

SP Lütjens - 2023 - research.rug.nl
Schizophrenia is a mental disorder that arises from abnormal neurodevelopment, led by
genetic and environmental factors. Several lines of evidence suggest the involvement of …

Immune dysfunction and childhood trauma in schizophrenia spectrum disorders

AS Enthoven - 2023 - research.rug.nl
Schizophrenia spectrum disorders (SSS) is a group of disorders in which patients suffer from
various symptoms such as delusions and hallucinations, as well as cognitive symptoms …

The role of the blood-brain barrier in psychiatric disorders

M Lačković, M Ivković, S Vićentić… - Srpski arhiv za …, 2022 - rfasper.fasper.bg.ac.rs
The blood-brain barrier (BBB) is formed by continuous, closely connected endothelial cells,
enveloped in the basal lamina, pericytes, and foot extensions of astrocytes. BBB has a vital …