For more than 50 years, evidence has accumulated that inflammation contributes to the
pathogenesis of hypertension. Immune cells have been observed in vessels and kidneys of …

Abstract Intracellular adhesion molecule 1 (ICAM-1) is one of the most extensively studied
inducible cell adhesion molecules which is responsible for several immune functions like T …

Simple Summary Acute kidney injury can result from multiple factors. The main cause is
reduced renal perfusion. Kidneys are susceptible to ischemia due to the anatomy of …

Introduction Leukocyte infiltration is an early event during cardiac remodeling frequently
leading to heart failure (HF). Integrins mediate leukocyte infiltration during inflammation …

Adhesion of monocytes to the vascular endothelium frequently leads to an inflammatory
response, which contributes to hypertension and vascular remodeling. Vascular cellular …

Background: Leukocyte adhesion to endothelium is an early inflammatory response and is
mainly controlled by the β2-integrins. However, the role of integrin CD11b/CD18 in the …

Epigallocatechin gallate (EGCG) has been shown to have antihypertensive activity.
However, the role of epigallocatechin gallate (EGCG) in improving vascular function via …

Toll-like receptor 4 (TLR4), a key pattern recognition receptor, initiates the innate immune
response and leads to chronic and acute inflammation. In the past decades, accumulating …

Lenvatinib, a multitarget tyrosine kinase inhibitor (TKI), increases the incidence of severe
hypertension and thus the incidence of cardiovascular complications. Inhibition of …

Inflammation and activation of the immune system are key molecular and cellular events in
the pathogenesis of cardiovascular diseases, including atherosclerosis, hypertension …