Association of Mutations in Replicative DNA Polymerase Genes with Human Disease: Possible Application of Drosophila Models for Studies

M Yamaguchi, S Cotterill - International Journal of Molecular Sciences, 2023 - mdpi.com
Replicative DNA polymerases, such as DNA polymerase α-primase, δ and ε, are multi-
subunit complexes that are responsible for the bulk of nuclear DNA replication during the S …

PRIM2 promotes cell cycle and tumor progression in p53-mutant lung cancer

T Wang, T Tang, Y Jiang, T He, L Qi, H Chang, Y Qiao… - Cancers, 2022 - mdpi.com
Simple Summary The mutation or inactivation of tumor suppressor genes is a key driving
force during tumorigenesis, among which, p53 mutation is a common feature of human …

Targets and Potential Mechanism of Scutellaria baicalensis in Treatment of Primary Hepatocellular Carcinoma Based on Bioinformatics Analysis

D Liu, Z Wang, L Zhong, C Xie, X Huang… - Journal of …, 2022 - Wiley Online Library
Objective. To analyze the target and potential mechanism of Scutellaria baicalensis (SB) in
the treatment of HCC based on bioinformatics, so as to provide suggestions for the …

[HTML][HTML] Landscape of the intratumroal microenvironment in bladder cancer: Implications for prognosis and immunotherapy

Z Bian, J Chen, C Liu, Q Ge, M Zhang, J Meng… - Computational and …, 2023 - Elsevier
Introduction This study aims to present the landscape of the intratumoral microenvironment
and by which establish a classification system that can be used to predict the prognosis of …

Identification of potential key genes and prognostic biomarkers of lung cancer based on bioinformatics

K Cai, Z Xie, Y Liu, J Wu, H Song, W Liu… - BioMed research …, 2023 - Wiley Online Library
Objective. To analyze and identify the core genes related to the expression and prognosis of
lung cancer including lung adenocarcinoma (LUAD) and lung squamous cell carcinoma …

Prognostic correlation between specialized capillary endothelial cells and lung adenocarcinoma

R Zhao, Y Ding, R Han, R Ding, J Liu, C Zhu, D Ding… - Heliyon, 2024 - cell.com
Background In-depth analysis of the functional changes occurring in endothelial cells (ECs)
involved in capillary formation can help to elucidate the mechanism of tumour vascular …

PRIM2: A Marker of MYC-driven Hyper-proliferation, Disease Progression, Tumor Aggressiveness and Poor Survival in Glioma Patients

R Sun, X Shao, F Akter, KR Zahid, S Yao… - Cancer Genomics & …, 2024 - cgp.iiarjournals.org
Abstract Background/Aim: Gliomas are the most prevalent brain tumors with metabolic
alterations playing a pivotal role in disease progression. However, the precise coordination …

A unique gene signature predicting recurrence-free survival in stage IA lung adenocarcinoma

SR Carr, H Wang, R Hudlikar, X Lu, MR Zhang… - The Journal of thoracic …, 2023 - Elsevier
Objective Resected stage IA lung adenocarcinoma has a reported 5-year recurrence-free
survival of 63% to 81%. A unique gene signature stratifying patients with early-stage lung …

Complete remission in leptomeningeal metastasis of NSCLC with rare EGFR-SEPT14 fusion treated with osimertinib combined with intrathecal chemotherapy with …

S Zheng, H Li, J Feng, C Jiang, Y Lin, Y Xie… - Anti-Cancer …, 2022 - journals.lww.com
Leptomeningeal metastasis (LM) is one of the most serious complications of non–small cell
lung cancer (NSCLC) without standard treatment guidelines and is always accompanied by …

基于GEO 数据库的小细胞肺癌lncRNA-miRNA-mRNA 网络的构建与潜在的诊治靶点分析

王曦帆, 朱传东, 陈芳芳 - 临床肿瘤学杂志, 2023 - manu65.magtech.com.cn
目的筛选参与小细胞肺癌(SCLC) 发生发展的ncRNAs, 预测其诊治的潜在靶点.
方法对人类肿瘤相关基因表达汇编(Gene Expression Omnibus, GEO) 数据库中获得的表达谱 …