Arsenic is a metalloid compound that is widely distributed in the environment. Human
exposure of this compound has been associated with increased cancer incidence. Although …

Arsenic is a well-documented carcinogen that also appears to be a valuable therapeutic tool
in cancer treatment. This creates a paradox for which no unified hypothesis has been …

Αn α-helical MA-3 domain appears in several translation initiation factors, including human
eukaryotic translation initiation factor 4G (eIF4G) and DAP-5/NAT1/p97, as well as in the …

Abstract ras gene mutation, which perpetually turns on the growth signal transduction
pathway, occurs frequently in many cancer types. The mouse epidermal JB6 cell line has …

Retinoic acid is one of the most promising drugs for chemotherapy and chemoprevention of
cancer. Either blocking activator protein-1 (AP-1) activity or activating retinoic acid response …

Previous studies have shown that c-Jun NH2-terminal kinase (JNK) belongs to the mitogen-
activated protein kinase (MAPK) family of signal transduction components that are rapidly …

Abstract Background Long intergenic noncoding RNAs (lincRNAs) have been shown to be
novel regulators for both transcription and posttranscriptional/translation. One of them …

In view of the rapid development of gene chips and high-throughput sequencing technology,
noncoding RNAs (ncRNas) form a high percentage of the mammalian genome. Two major …

Transformation suppressor Pdcd4 is downregulated in transformed (Tx) mouse epidermal
JB6 RT101 cells relative to transformation-resistant (P−) and susceptible (P+) variants …

(–)-Epigallocatechin gallate (EGCG) and theaflavins are believed to be the key active
components in tea for the chemoprevention of cancer. However, the molecular mechanisms …