Exosomes as potential functional nanomaterials for tissue engineering

Y Yao, Y Jiang, J Song, R Wang, Z Li… - Advanced …, 2023 - Wiley Online Library
Exosomes are cell‐derived extracellular vesicles of 40–160 nm diameter, which carry
numerous biomolecules and transmit information between cells. They are used as functional …

Recent advances using MXenes in biomedical applications

IC Lee, YCE Li, JL Thomas, MH Lee, HY Lin - Materials Horizons, 2024 - pubs.rsc.org
An MXene is a novel two-dimensional transition metal carbide or nitride, with a typical
formula of Mn+ 1XnTx (M= transition metals, X= carbon or nitrogen, and T= functional …

Engineered cocultures of iPSC-derived atrial cardiomyocytes and atrial fibroblasts for modeling atrial fibrillation

GE Brown, YD Han, AR Michell, OT Ly, CG Vanoye… - Science …, 2024 - science.org
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia treatable with
antiarrhythmic drugs; however, patient responses remain highly variable. Human induced …

Recent advances in bioprinting technologies for engineering cardiac tissue

T Agarwal, GM Fortunato, SY Hann, B Ayan… - Materials Science and …, 2021 - Elsevier
Annually increasing incidence of cardiac-related disorders and cardiac tissue's minimal
regenerative capacity have motivated the researchers to explore effective therapeutic …

Recent fabrications and applications of cardiac patch in myocardial infarction treatment

M Li, H Wu, Y Yuan, B Hu, N Gu - View, 2022 - Wiley Online Library
Myocardial infarction caused by coronary artery obstruction results in the loss of heart
muscle, which is subsequently replaced by scar tissue with limited therapeutic options …

Stem cell‐derived extracellular vesicles reduce the expression of molecules involved in cardiac hypertrophy—In a model of human-induced pluripotent stem cell …

A Constantin, IK Comarița, N Alexandru… - Frontiers in …, 2022 - frontiersin.org
Cardiac pathological hypertrophy is the major risk factor that usually progresses to heart
failure. We hypothesized that extracellular vesicles (EVs), known to act as important …

Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes

RD Johnson, M Lei, JH McVey, P Camelliti - Cellular and Molecular Life …, 2023 - Springer
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the
potential to remuscularize infarcted hearts but their arrhythmogenicity remains an obstacle to …

Stem cells derived exosomes and biomaterials to modulate autophagy and mend broken hearts

N Sareen, A Srivastava, KN Alagarsamy… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Autophagy maintains cellular homeostasis and plays a crucial role in managing pathological
conditions including ischemic myocardial injury leading to heart failure (HF). Despite …

Multifunctional conductive biomaterials as promising platforms for cardiac tissue engineering

A Mousavi, S Vahdat, N Baheiraei… - ACS biomaterials …, 2020 - ACS Publications
Adult cardiomyocytes are terminally differentiated cells that result in minimal intrinsic
potential for the heart to self-regenerate. The introduction of novel approaches in cardiac …

Stem cell-based therapy in cardiac repair after myocardial infarction: Promise, challenges, and future directions

W Yan, Y Xia, H Zhao, X Xu, X Ma, L Tao - Journal of Molecular and …, 2024 - Elsevier
Stem cells represent an attractive resource for cardiac regeneration. However, the survival
and function of transplanted stem cells is poor and remains a major challenge for the …