Existing literature provides extended evidence of the close relationship between stress
dysregulation, environmental insults, and psychosis onset. Early stress can sensitize …

Advances in genomics have enabled the development of polygenic scores (PGS),
sometimes called polygenic risk scores, in the context of multifactorial diseases and …

Precision psychiatry has emerged as part of the shift to personalized medicine and builds on
frameworks such as the US National Institute of Mental Health Research Domain Criteria …

Despite its enduring relevance as the single most effective and important evidence-based
treatment for schizophrenia, underutilization of clozapine remains considerable. To a …

Using Swedish registers, we examine whether the prescription of and the response to
antidepressants (AD), mood stabilizers (MS), and antipsychotics (AP) in the treatment of …

The validation of nosological diagnoses in psychiatry remains a conundrum. Leonhard's
(1979) nosology seems to be one of the few acceptable alternative categorical models to …

People with mental disorders, such as psychosis or autism spectrum disorder (ASD), often
present impairments in social cognition (SC), which may cause significant difficulties in real …

Background Depression has been linked to an increased risk of cardiovascular and
respiratory diseases; however, its impact on cardiac and lung function remains unclear …

Schizophrenia is often regarded as a disorder of premature aging. We investigated (a)
whether polygenic risk for schizophrenia (PRSsch) relates to pace of epigenetic aging and …

Background The identification of suitable biomarkers is of crucial clinical importance for the
early diagnosis of treatment-resistant schizophrenia (TRS). This study aims to …