The progressive degeneration of the skeletal musculature in Duchenne muscular dystrophy
is accompanied by reactive myofibrosis, fat substitution, and chronic inflammation. Fibrotic …

Ageing is a complex biological process associated with increased morbidity and mortality.
Nine classic, interdependent hallmarks of ageing have been proposed involving genetic and …

Long-duration mission (LDM) astronauts from the International Space Station (ISS)(> 180
ISS days) revealed a close-to-normal sarcolemmal nitric oxide synthase type-1 (NOS1) …

Introduction Skeletal muscles contain large numbers of high-molecular-mass protein
complexes in elaborate membrane systems. Integral membrane proteins are involved in …

Voluntary striated muscles are characterized by a highly complex and dynamic proteome
that efficiently adapts to changed physiological demands or alters considerably during …

Sarcopenia is a multifactorial condition characterized by loss of muscle mass. It poses
significant health risks in older adults worldwide. Both pharmacological and non …

Autophagy dysregulation is commonplace in the pathogenesis of several invalidating
diseases, such as musculoskeletal diseases. Polyamines, as spermidine and spermine, are …

Background Exercise is an effective strategy to prevent sarcopenia, but high physical
inactivity in the elderly requires alternative therapeutic approaches. Exercise mimetics are …

As people age, their skeletal muscle (SkM) experiences a decline in mitochondrial
functionality and density, which leads to decreased energy production and increased …

Skeletal muscle is a heterogeneous tissue composed of different types of muscle fibers,
demonstrating substantial plasticity. Physiological or pathological stimuli can induce …