Aggregation of specific proteins are histopathological hallmarks of several
neurodegenerative diseases, such as, Amyloid β (Aβ) plaques and tau neurofibrillary …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …

Alzheimer's disease (AD) is defined as a severe chronic degenerative neurological disease
in human. The pathogenic mechanism of AD has been convincingly elucidated by the …

There is a huge need for novel therapeutic and preventative approaches to Alzheimer's
disease (AD) and neuroinflammation seems to be one of the most fascinating solutions. The …

Physical exercise is of great significance for maintaining human health. Exercise can
provide varying degrees of benefits to cognitive function at all stages of life cycle. Currently …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane
immune receptor that is mainly expressed on microglia in the brain and macrophages in the …

Cholesterol homeostasis is vital for brain function. Brain cholesterol is locally synthesized,
with varying synthesis capacities across different cell types. Moreover, brain cholesterol …

Alzheimer's disease (AD), the most common type of senile dementia, includes the complex
pathogenesis of abnormal deposition of amyloid beta-protein (Aβ), phosphorylated tau (p …

Alzheimer's disease (AD) is the most common neurodegenerative disease, resulting in the
loss of cognitive ability and memory. However, there is no specific treatment to …

The morphological plasticity of microglia has fascinated neuroscientists for 100 years.
Attempts to classify functional phenotypes are hampered by similarities between …