Nanoenabled modulation of acidic tumor microenvironment reverses anergy of infiltrating T cells and potentiates anti-PD-1 therapy

YX Zhang, YY Zhao, J Shen, X Sun, YI Liu, H Liu… - Nano …, 2019 - ACS Publications
While tumor-infiltrating cytotoxic T lymphocytes play a critical role in controlling tumor
development, they are generally impotent in an acidic tumor microenvironment. Systemic …

Recent advances in stimuli‐responsive theranostic systems with aggregation‐induced emission characteristics

JJ Hu, W Jiang, L Yuan, C Duan, Q Yuan, Z Long… - …, 2021 - Wiley Online Library
Theranostic systems by integrating the tumor imaging and tumor therapeutic capabilities into
one platform have attracted numerous attentions from worldwide researchers. Despite the …

Tumor microenvironment responsive nanogel for the combinatorial antitumor effect of chemotherapy and immunotherapy

Q Song, Y Yin, L Shang, T Wu, D Zhang, M Kong… - Nano …, 2017 - ACS Publications
A biomimetic nanogel with tumor microenvironment responsive property is developed for the
combinatorial antitumor effects of chemotherapy and immunotherapy. Nanogels are …

A tailored DNA nanoplatform for synergistic RNAi‐/chemotherapy of multidrug‐resistant tumors

J Liu, L Song, S Liu, S Zhao, Q Jiang… - Angewandte Chemie …, 2018 - Wiley Online Library
Multidrug resistance (MDR) is a major obstacle in the clinical treatment of cancer. Herein, a
facile strategy is reported to construct a versatile DNA nanostructure as a co‐delivery vector …

The progress and prospect of zeolitic imidazolate frameworks in cancer therapy, antibacterial activity, and biomineralization

A Maleki, MA Shahbazi, V Alinezhad… - Advanced healthcare …, 2020 - Wiley Online Library
The progressive development of zeolitic imidazolate frameworks (ZIFs), as a subfamily of
metal‐organic frameworks (MOFs), and their unique features, including tunable pore size …

Recent advances in targeted nanomedicine as promising antitumor therapeutics

S Hejmady, R Pradhan, A Alexander, M Agrawal… - Drug discovery today, 2020 - Elsevier
Highlights•Nanocarriers with the ability to target tumors are being increasingly explored.•
Nanomedicine aid in maintaining a balance between efficacy and toxicity.•Recent advances …

Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer

Q Li, T Qin, Z Bi, H Hong, L Ding, J Chen, W Wu… - Nature …, 2020 - nature.com
Resistance development to one chemotherapeutic reagent leads frequently to acquired
tolerance to other compounds, limiting the therapeutic options for cancer treatment. Herein …

Fe3O4@PVP@DOX magnetic vortex hybrid nanostructures with magnetic-responsive heating and controlled drug delivery functions for precise medicine of cancers

X Wang, Y Qi, Z Hu, L Jiang, F Pan, Z Xiang… - … Composites and Hybrid …, 2022 - Springer
Precise magnetic hyperthermia/chemo synergistic therapy has attracted great attention as a
promising cancer therapy. However, how to improve the hyperthermia efficiency and …

Tumor microenvironment targeted nanotherapy

C Fernandes, D Suares, MC Yergeri - Frontiers in pharmacology, 2018 - frontiersin.org
Recent developments in nanotechnology have brought new approaches to cancer
diagnosis and therapy. While enhanced permeability and retention effect promotes nano …

Green tea catechin dramatically promotes RNAi mediated by low-molecular-weight polymers

W Shen, Q Wang, Y Shen, X Gao, L Li, Y Yan… - ACS central …, 2018 - ACS Publications
Cytosolic delivery is the major challenge that limits the clinical translation of siRNA-based
therapeutics. Although thousands of polymers have been developed for siRNA delivery, the …