With recent advances in polymer chemistry, materials science, and nanotechnology, pH-
responsive polymers have a significant impact in a number of diverse fields. Fundamental …

Multiple drug resistance is a persistent obstacle for efficient chemotherapy of cancer. Herein,
we report a novel drug delivery platform. A zeolitic imidazole framework-8 (ZIF-8) film with a …

There is a continuing quest to rationally fabricate polymeric biomaterials with both high
transfection efficiency and minimal toxicity for the emerging opportunities in small interfering …

Cancer therapy continues to be a huge challenge as most chemotherapeutic agents exert
serious adverse effects on healthy organs. Chemotherapeutic agents lack selective targeting …

Within the field of gene therapy, there is a considerable need for the development of non-
viral vectors that are able to compete with the efficiency obtained by viral vectors, while …

The applications of nanoparticulate drug delivery have received abundant interest in the
field of cancer diagnosis and treatment. By virtue of their unique features and design …

Although small interfering RNA (siRNA) therapy has achieved great progress, unwanted
gene inhibition in normal tissues severely limits its extensive clinical applications due to …

Developing smart photosensitizers that are sensitive to tumor-specific signals for minimal
side effects and enhanced antitumor efficacy is a tremendous challenge for tumor …

Highlights•siRNAs are effective and powerful gene tools in cancer therapy.•Smart
nanocarriers can tune the pharmacokinetics and therapy efficacy of siRNAs.•All-in-one …

Non-healing wounds have long been the subject of scientific and clinical investigations.
Despite breakthroughs in understanding the biology of delayed wound healing, only limited …