Multidrug resistance is one of the major problems in chemotherapy, and exploiting impactful
targets to reverse drug resistance of most tumors remains a difficult problem. In this study …

Natural polysaccharides are natural biomaterials that have become candidate materials for
nano-drug delivery systems due to their excellent biodegradability and biocompatibility …

Cancer is the second-most lethal global disease, as per health reports, and is responsible
for around 70% of deaths in low-and middle-income countries. Endometrial cancer is one of …

The targeted nanoagents have shown great potential clinically for cancer therapy.
Traditional targeted nanodrugs are usually prepared through surface postmodification …

Using non-covalent interactions between nucleic acids (DNA, siRNA, miRNA, and mRNA)
with peptides or nucleopeptides is a promising strategy to construct supramolecular …

The inherent features of small interfering RNA (siRNA), including a relatively high molecular
weight, negative charge, and hydrophilic nature, lead to the widespread use of cationic …

In this article, a novel graft polymeric micelle with targeting function ground on aptamer
AS1411 was synthesized. The micelle was based on chitosan-ss-polyethylenimine-urocanic …

New molecular motifs that can act as pH-regulating triggers for amphiphilic, pH-sensitive
block copolymers are investigated. Inspired by the mechanism of action of pH-indicators …

The extremely low efficient cytosolic release of the internalized siRNA has emerged recently
as a central issue for siRNA delivery, while there is a lack of guidelines to facilitate the …

Small interfering RNA (siRNA) has extensive potential for the treatment of non-small cell
lung cancer (NSCLC). While both cationic lipids and polymers have demonstrated promise …