Stress generation posits that (a) individuals at-risk for psychopathology may inadvertently
experience higher rates of prospective dependent stress (ie, stressors that are in part …

The manifestations of chronic insomnia undergo age-related changes. In younger infants
and children, behavioral insomnia emerges as the most prevalent form and typically …

Late-life depression (LLD) is a multifactorial disorder, with susceptibility and vulnerability
potentially influenced by gene-environment interaction. The aim of this study was to …

Plasticity is the ability to modify brain and behavior and allows the transition from
psychopathology to mental wellbeing. High plasticity has been associated with high …

Background Circadian rhythm was involved in the pathogenesis of depression. The
detection of circadian genes and white matter (WM) integrity achieved increasing focus for …

Plasticity is increasingly recognized as a critical concept in psychiatry and mental health
because it allows the reorganization of neural circuits and behavior during the transition …

Introduction Developmental changes due to early life variations in the serotonin system
affect stress-related behavior and neuroplasticity in adulthood. These outcomes can be …

Background Methylation of serotonin-related genes has been proposed as a plausible gene-
by-environment link which may mediate environmental stress, depressive and anxiety …

Objective: Neuropeptide Y (NPY) is a powerful regulator of anxious states, including social
anxiety, but evidence from human genetic studies is limited. Associations of common gene …

Notwithstanding the huge progress in molecular and cellular neuroscience, our ability to
understand the brain and develop effective treatments promoting mental health is still …