Brain metabolism perturbation can contribute to traits and diseases. We conducted the first
large-scale CSF and brain genome-wide association studies, which identified 219 …

While circulating metabolites have been increasingly linked to cancer risk, the causality
underlying these associations remains largely uninterrogated. We conducted a …

Finasteride may cause low libido and erectile dysfunction and the product label of
finasteride also includes post-marketing reactions of sexual dysfunction that continued after …

Mendelian randomization has been widely used to assess the causal effect of a heritable
exposure variable on an outcome of interest, using genetic variants as instrumental …

The biological mechanisms through which most non-protein-coding genetic variants affect
disease risk are unknown. To investigate the gene-regulatory cascades that ensue from …

Background Bipolar disorder (BPD) is a debilitating mood disorder with an unclear
aetiology. A better understanding of the underlying pathophysiological mechanisms will help …

Background Preventive measures and treatments for psychiatric disorders are limited.
Circulating metabolites are potential candidates for biomarker and therapeutic target …

Genetic studies of the metabolome can uncover enzymatic and transport processes shaping
human metabolism. Using WES-based rare variant aggregation testing to detect genes …

The human metabolism constantly responds to stimuli such as food intake, fasting, exercise,
and stress, triggering adaptive biochemical processes across multiple metabolic pathways …

Introduction Increased and excess adiposity is associated with increased risk of endometrial
cancer (EC) and both of these are associated with circulating metabolite profiles. However …