Onco-Breastomics: An Eco-Evo-Devo Holistic Approach
Known as a diverse collection of neoplastic diseases, breast cancer (BC) can be
hyperbolically characterized as a dynamic pseudo-organ, a living organism able to build a …
hyperbolically characterized as a dynamic pseudo-organ, a living organism able to build a …
Pathogenic variants in human DNA damage repair genes mostly arose in recent human history
Background Genome stability is maintained by the DNA damage repair (DDR) system
composed of multiple DNA repair pathways of hundreds of genes. Germline pathogenic …
composed of multiple DNA repair pathways of hundreds of genes. Germline pathogenic …
Using Portuguese BRCA pathogenic variation as a model to study the impact of human admixture on human health
Admixture occurs between different ethnic human populations. The global colonization in
recent centuries by Europeans led to the most significant admixture in human history. While …
recent centuries by Europeans led to the most significant admixture in human history. While …
Classification of MLH1 Missense VUS Using Protein Structure-Based Deep Learning-Ramachandran Plot-Molecular Dynamics Simulations Method
Pathogenic variation in DNA mismatch repair (MMR) gene MLH1 is associated with Lynch
syndrome (LS), an autosomal dominant hereditary cancer. Of the 3798 MLH1 germline …
syndrome (LS), an autosomal dominant hereditary cancer. Of the 3798 MLH1 germline …
[PDF][PDF] Multiple TP53 p. R337H haplotypes and implications for tumor susceptibility
The germline TP53 p. R337H mutation is reported as the most common germline TP53
variant. It exists at a remarkably high frequency in the population of southeast Brazil as …
variant. It exists at a remarkably high frequency in the population of southeast Brazil as …