[HTML][HTML] COVID-19 and cellular senescence
CA Schmitt, T Tchkonia, LJ Niedernhofer… - Nature Reviews …, 2023 - nature.com
The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …
Advances and utility of the human plasma proteome
The study of proteins circulating in blood offers tremendous opportunities to diagnose,
stratify, or possibly prevent diseases. With recent technological advances and the urgent …
stratify, or possibly prevent diseases. With recent technological advances and the urgent …
[HTML][HTML] Virus-induced senescence is a driver and therapeutic target in COVID-19
S Lee, Y Yu, J Trimpert, F Benthani, M Mairhofer… - Nature, 2021 - nature.com
Derailed cytokine and immune cell networks account for the organ damage and the clinical
severity of COVID-19 (refs.,,–). Here we show that SARS-CoV-2, like other viruses, evokes …
severity of COVID-19 (refs.,,–). Here we show that SARS-CoV-2, like other viruses, evokes …
[HTML][HTML] Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19
Although critical for host defense, innate immune cells are also pathologic drivers of acute
respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus …
respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus …
[HTML][HTML] Social media efficacy in crisis management: effectiveness of non-pharmaceutical interventions to manage COVID-19 challenges
The new identified virus COVID-19 has become one of the most contagious diseases in
human history. The ongoing coronavirus has created severe threats to global mental health …
human history. The ongoing coronavirus has created severe threats to global mental health …
Mass spectrometry‐based high‐throughput proteomics and its role in biomedical studies and systems biology
There are multiple reasons why the next generation of biological and medical studies
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …
High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion
A deeper understanding of COVID‐19 on human molecular pathophysiology is urgently
needed as a foundation for the discovery of new biomarkers and therapeutic targets. Here …
needed as a foundation for the discovery of new biomarkers and therapeutic targets. Here …
[HTML][HTML] Interpreting biologically informed neural networks for enhanced proteomic biomarker discovery and pathway analysis
The incorporation of machine learning methods into proteomics workflows improves the
identification of disease-relevant biomarkers and biological pathways. However, machine …
identification of disease-relevant biomarkers and biological pathways. However, machine …
[HTML][HTML] Plasma proteomic signature predicts who will get persistent symptoms following SARS-CoV-2 infection
Background The majority of those infected by ancestral Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) during the UK first wave (starting March 2020) did not require …
Coronavirus 2 (SARS-CoV-2) during the UK first wave (starting March 2020) did not require …
[HTML][HTML] COVIDomics: The proteomic and metabolomic signatures of COVID-19
M Costanzo, M Caterino, R Fedele, A Cevenini… - International journal of …, 2022 - mdpi.com
Omics-based technologies have been largely adopted during this unprecedented global
COVID-19 pandemic, allowing the scientific community to perform research on a large scale …
COVID-19 pandemic, allowing the scientific community to perform research on a large scale …