Targeted deep learning classification and feature extraction for clinical diagnosis

Y Tsai, V Nanthakumar, S Mohammadi, SA Baldwin… - Iscience, 2023 - cell.com
Protein biomarkers can be used to characterize symptom classes, which describe the
metabolic or immunodeficient state of patients during the progression of a specific disease …

[HTML][HTML] Deciphering COVID-19 host transcriptomic complexity and variations for therapeutic discovery against new variants

J Xing, R Shankar, M Ko, K Zhang, S Zhang, A Drelich… - Iscience, 2022 - cell.com
The molecular manifestations of host cells responding to SARS-CoV-2 and its evolving
variants of infection are vastly different across the studied models and conditions, imposing …

Integrative proteomics and metabolomics study reveal enhanced immune responses by COVID‐19 vaccine booster shot against Omicron SARS‐CoV‐2 infection

B Wang, W Yang, Y Tong, M Sun… - Journal of Medical …, 2023 - Wiley Online Library
Since its outbreak in late 2021, the Omicron variant of severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2) has been widely reported to be able to evade neutralizing …

Proteomics Applications in Toxoplasma gondii: Unveiling the Host–Parasite Interactions and Therapeutic Target Discovery

B Deng, L Vanagas, AM Alonso, SO Angel - Pathogens, 2023 - mdpi.com
Toxoplasma gondii, a protozoan parasite with the ability to infect various warm-blooded
vertebrates, including humans, is the causative agent of toxoplasmosis. This infection poses …

[HTML][HTML] Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients

A Bauer, E Pachl, JC Hellmuth, N Kneidinger… - … et Biophysica Acta (BBA …, 2023 - Elsevier
SARS-CoV-2 remains an acute threat to human health, endangering hospital capacities
worldwide. Previous studies have aimed at informing pathophysiologic understanding and …

Development of a proteomic signature associated with severe disease for patients with COVID-19 using data from 5 multicenter, randomized, controlled, and …

S Castro-Pearson, S Samorodnitsky, K Yang… - Scientific reports, 2023 - nature.com
Significant progress has been made in preventing severe COVID-19 disease through the
development of vaccines. However, we still lack a validated baseline predictive biologic …

COVID-19 Salivary Protein Profile: Unravelling Molecular Aspects of SARS-CoV-2 Infection

E Esteves, VM Mendes, B Manadas, R Lopes… - Journal of Clinical …, 2022 - mdpi.com
COVID-19 is the most impacting global pandemic of all time, with over 600 million infected
and 6.5 million deaths worldwide, in addition to an unprecedented economic impact …

[HTML][HTML] Foresight in clinical proteomics: current status, ethical considerations, and future perspectives

F Mundt, NJW Albrechtsen, SP Mann, P Treit… - Open Research …, 2023 - ncbi.nlm.nih.gov
With the advent of robust and high-throughput mass spectrometric technologies and
bioinformatics tools to analyze large data sets, proteomics has penetrated broadly into basic …

Individual COVID‐19 disease trajectories revealed by plasma proteomics

D Memon, I Barrio‐Hernandez… - EMBO molecular medicine, 2021 - embopress.org
Since the start of 2020, the world has been upended by the pandemic caused by the severe
acute respiratory coronavirus type 2 (SARS‐CoV‐2), the causative agent of coronavirus …

Network embedding across multiple tissues and data modalities elucidates the context of host factors important for COVID-19 infection

Y Hu, G Rehawi, L Moyon, N Gerstner, C Ogris… - Frontiers in …, 2022 - frontiersin.org
COVID-19 is a heterogeneous disease caused by SARS-CoV-2. Aside from infections of the
lungs, the disease can spread throughout the body and damage many other tissues, leading …