Recent developments in the immunopathology of COVID‐19

H Zhang, Y Sun, Y Wang, D Yazici, D Azkur, I Ogulur… - Allergy, 2023 - Wiley Online Library
There has been an important change in the clinical characteristics and immune profile of
Coronavirus disease 2019 (COVID‐19) patients during the pandemic thanks to the …

Histones: The critical players in innate immunity

X Li, Y Ye, K Peng, Z Zeng, L Chen, Y Zeng - Frontiers in immunology, 2022 - frontiersin.org
The highly conserved histones in different species seem to represent a very ancient and
universal innate host defense system against microorganisms in the biological world …

The role of extracellular histones in COVID‐19

F de Vries, J Huckriede, K Wichapong… - Journal of Internal …, 2023 - Wiley Online Library
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) had spread from
China and, within 2 months, became a global pandemic. The infection from this disease can …

A review: Highlighting the links between epigenetics, COVID-19 infection, and vitamin D

A Foolchand, S Mazaleni, T Ghazi… - International Journal of …, 2022 - mdpi.com
The highly transmittable and infectious COVID-19 remains a major threat worldwide, with the
elderly and comorbid individuals being the most vulnerable. While vaccines are currently …

[HTML][HTML] Fibrinogen, fibrin, and fibrin degradation products in COVID-19

K Kangro, AS Wolberg, MJ Flick - Current drug targets, 2022 - ncbi.nlm.nih.gov
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the highly
pathogenic and highly transmissible human coronavirus that is the causative agent for the …

Anti-inflammatory effects and decreased formation of neutrophil extracellular traps by enoxaparin in COVID-19 patients

S Saithong, W Saisorn, P Tovichayathamrong… - International Journal of …, 2022 - mdpi.com
Neutrophil Extracellular Traps (NETs) are a contributing factor of vascular thrombosis and
alveolar damage in COVID-19 patients. As enoxaparin is currently used to inhibit vascular …

What is the impact of circulating histones in COVID-19: a systematic review

D Ligi, RV Giglio, BM Henry, G Lippi… - Clinical Chemistry and …, 2022 - degruyter.com
The infectious respiratory condition COVID-19 manifests a clinical course ranging from
mild/moderate up-to critical systemic dysfunction and death linked to thromboinflammation …

Self-DNA driven inflammation in COVID-19 and after mRNA-based vaccination: lessons for non-COVID-19 pathologies

M Heil - Frontiers in Immunology, 2024 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented
concentration of economic and research efforts to generate knowledge at unequalled speed …

Do circulating histones represent the missing link among COVID-19 infection and multiorgan injuries, microvascular coagulopathy and systemic hyperinflammation?

D Ligi, R Maniscalco, M Plebani, G Lippi… - Journal of Clinical …, 2022 - mdpi.com
Several studies shed light on the interplay among inflammation, thrombosis, multi-organ
failures and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

The polyanionic drug suramin neutralizes histones and prevents endotheliopathy

N Villalba, AM Sackheim, MA Lawson… - The Journal of …, 2023 - journals.aai.org
Drugs are needed to protect against the neutrophil-derived histones responsible for
endothelial injury in acute inflammatory conditions such as trauma and sepsis. Heparin and …