Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

In recent years dietary interventions have become a promising tool in cancer treatment and
have demonstrated a powerful ability to alter metabolism and tumor growth, development …

Availability of the amino acid methionine shows remarkable effects on the physiology of
individual cells and whole organisms. For example, most cancer cells, but not normal cells …

Methionine addiction is a fundamental and general hallmark of cancer. Methionine addiction
prevents cancer cells, but not normal cells from proliferation under methionine restriction …

Methionine addiction, a fundamental and general hallmark of cancer, known as the Hoffman
Effect, is due to altered use of methionine for increased and aberrant transmethylation …

Malignant cells often demonstrate a proliferative advantage when compared to non-
malignant cells. However, the rapid growth and metabolism required for survival can also …

Background/Aim: Rectal cancer is a recalcitrant disease with limited treatment options. Pre-
clinical studies have shown the efficacy of methionine restriction with a low-methionine diet …

Background/Aim: Methionine addiction is a fundamental and general hallmark of cancer,
termed the Hoffman effect. Methionine addiction is due to excessive use of and dependence …

All cancer cell types are methionine-addicted, which is termed the Hoffman effect. Cancer
cells, unlike normal cells, cannot survive without large amount of methionine. In general …

All types of cancer cells are addicted to methionine, which is known as the Hoffman effect.
Restricting methionine inhibits the growth and proliferation of all tested types of cancer cells …