Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

In contrast to single-cell approaches for measuring gene expression and DNA accessibility,
single-cell methods for analyzing histone modifications are limited by low sensitivity and …

In vivo cell fate conversions have emerged as potential regeneration-based therapeutics for
injury and disease. Recent studies reported that ectopic expression or knockdown of certain …

Spinal cord injury (SCI) involves diverse injury responses in different cell types in a
temporally and spatially specific manner. Here, using single-cell transcriptomic analyses …

Hematopoietic cell transplantation after myeloablative conditioning has been used to treat
various genetic metabolic syndromes but is largely ineffective in diseases affecting the brain …

The amygdala processes positive and negative valence and contributes to addiction, but the
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …

Reprogramming brain-resident glial cells into clinically relevant induced neurons (iNs) is an
emerging strategy toward replacing lost neurons and restoring lost brain functions. A …

Microglia, the resident immune cells in the retina and nervous system, make irreplaceable
contributions to the maintenance of normal homeostasis and immune surveillance of these …

The regenerative capacity of neurons is limited in the central nervous system (CNS), with
irreversible neuronal loss upon insult. In contrast, microglia exhibit extraordinary capacity for …