Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a
master switch in establishing an intricate link between inflammation and cancer. A wide …

Tumor necrosis factor (TNF) is a key mediator in the inflammatory response which is
implicated in the onset of a number of diseases. Research on TNF led to the characterization …

Prolonged and repeated exposure of the skin to ultraviolet light (UV) leads not only to aging
of the skin but also increases the incidence of non-melanoma skin cancer (NMSC). Damage …

We previously reported that expression of angiogenesis factors interleukin‐8 (IL‐8) and
vascular endothelial growth factor (VEGF) is promoted by coactivation of transcription factors …

Generation of reactive oxygen species (ROS) stimulates transcription by activating
transcription factors activator protein 1 (AP-1) and nuclear factor κB (NF-κB). The mouse …

Transformation suppressor Pdcd4 is downregulated in transformed (Tx) mouse epidermal
JB6 RT101 cells relative to transformation-resistant (P−) and susceptible (P+) variants …

Objective Pro-inflammatory mechanisms may explain the increased ovarian cancer risk
linked to more lifetime ovulations, endometriosis, and exposure to talc and asbestos, as well …

NF-κB activation is required for TNF-α-induced transformation of JB6 mouse epidermal cells.
Deficient activation of p65 contributes to the lack of NF-κB activation in transformation …

There are still many unanswered questions regarding the processes by which extracellular
signals are transduced from plasma-membrane receptors to the transcription machinery in …

Prostate carcinogenesis involves transformation of zinc-accumulating normal epithelial cells
to malignant cells, which do not accumulate zinc. In this study, we demonstrate by …