Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery
Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …
Characterization and therapeutic use of extracellular vesicles derived from platelets
T Spakova, J Janockova, J Rosocha - International Journal of Molecular …, 2021 - mdpi.com
Autologous blood products, such as platelet-rich plasma (PRP), are gaining increasing
interest in different fields of regenerative medicine. Although growth factors, the main …
interest in different fields of regenerative medicine. Although growth factors, the main …
[HTML][HTML] Biological reference materials for extracellular vesicle studies
S Valkonen, E Van Der Pol, A Böing, Y Yuana… - European Journal of …, 2017 - Elsevier
Extracellular vesicles (EVs) mediate normal physiological homeostasis and pathological
processes by facilitating intercellular communication. Research of EVs in basic science and …
processes by facilitating intercellular communication. Research of EVs in basic science and …
Quantitative increases of extracellular vesicles in prolonged cold storage of platelets increases the potential to enhance fibrin clot formation
J Nash, A Davies, CV Saunders… - Transfusion …, 2023 - Wiley Online Library
Background Platelet derived extracellular vesicles (EVs) display a pro‐coagulant phenotype
and are generated throughout platelet concentrate (PC) storage. Cold storage (CS) of PCs is …
and are generated throughout platelet concentrate (PC) storage. Cold storage (CS) of PCs is …
Platelet-derived microparticles analysis: Techniques, challenges and recommendations
J Kailashiya - Analytical biochemistry, 2018 - Elsevier
Platelet-derived microparticles (PMP) are nano size fragments (100–1000 nm) released
from platelets under various physiological and pathological conditions. PMP are the most …
from platelets under various physiological and pathological conditions. PMP are the most …
Lipid mediators in platelet concentrate and extracellular vesicles: Molecular mechanisms from membrane glycerophospholipids to bioactive molecules
Platelets are collected for transfusion to patients with different haematological disorders, and
for logistical reasons, platelets are stored as concentrates. Despite carefully controlled …
for logistical reasons, platelets are stored as concentrates. Despite carefully controlled …
Platelet transfusion in critical care and surgery: evidence-based review of contemporary practice and future directions
EW Etchill, SP Myers, JS Raval, A Hassoune… - Shock, 2017 - journals.lww.com
Thrombocytopenia is prevalent in critical care, surgical, and trauma settings. Despite the fact
that a significant proportion of these patients receive platelet transfusion during their hospital …
that a significant proportion of these patients receive platelet transfusion during their hospital …
[HTML][HTML] Complementary roles of platelet αIIbβ3 integrin, phosphatidylserine exposure and cytoskeletal rearrangement in the release of extracellular vesicles
ACA Heinzmann, MFA Karel, DM Coenen, T Vajen… - Atherosclerosis, 2020 - Elsevier
Background and aims Platelets can release extracellular vesicles (EVs) upon stimulation
with various agonists. Interestingly, platelets from patients with Glanzmann thrombasthenia …
with various agonists. Interestingly, platelets from patients with Glanzmann thrombasthenia …
[HTML][HTML] Impact of production methods and storage conditions on extracellular vesicles in packed red blood cells and platelet concentrates
M Ebeyer-Masotta, T Eichhorn, MB Fischer… - … and Apheresis Science, 2024 - Elsevier
The use of blood and blood products can be life-saving, but there are also certain risks
associated with their administration and use. Packed red blood cells (pRBCs) and platelet …
associated with their administration and use. Packed red blood cells (pRBCs) and platelet …
Platelet-derived extracellular vesicles play an important role in platelet transfusion therapy
Z Cai, J Feng, N Dong, P Zhou, Y Huang, H Zhang - Platelets, 2023 - Taylor & Francis
Extracellular vesicles (EVs) contain the characteristics of their cell of origin and mediate cell-
to-cell communication. Platelet-derived extracellular vesicles (PEVs) not only have …
to-cell communication. Platelet-derived extracellular vesicles (PEVs) not only have …