Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …

The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …

The blood-brain barrier (BBB) is a dynamic, highly selective barrier primarily formed by
endothelial cells connected by tight junctions that separate the circulating blood from the …

Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal
transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable …

Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

Post-injury epilepsy (PIE) is a common complication following brain insults, including
ischemic, and traumatic brain injuries. At present, there are no means to identify the patients …

Glutamate-mediated excitotoxicity, neuroinflammation, and oxidative stress are common
underlying events in neurodegeneration. This pathogenic “triad” characterizes the …

Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature
and inflammation as important players in epileptogenic processes, with a specific emphasis …

Epilepsy is a chronic neurological disorder characterized by recurring spontaneous
seizures. Drug resistance appears in 30% of patients and it can lead to premature death …

Epilepsy is a common chronic consequence of traumatic brain injury (TBI), contributing to
increased morbidity and mortality for survivors. As post-traumatic epilepsy (PTE) is drug …