Reverse vaccinology: developing vaccines in the era of genomics
A Sette, R Rappuoli - Immunity, 2010 - cell.com
The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
Immunodominance: a pivotal principle in host response to viral infections
A Akram, RD Inman - Clinical immunology, 2012 - Elsevier
We encounter pathogens on a daily basis and our immune system has evolved to mount an
immune response following an infection. An interesting phenomenon that has evolved in …
immune response following an infection. An interesting phenomenon that has evolved in …
Influence of HLA-C expression level on HIV control
A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant
genome-wide effect on HIV control in European Americans and is also associated with the …
genome-wide effect on HIV control in European Americans and is also associated with the …
A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control
HIV-1 sequence diversity is affected by selection pressures arising from host genomic
factors. Using paired human and viral data from 1071 individuals, we ran> 3000 genome …
factors. Using paired human and viral data from 1071 individuals, we ran> 3000 genome …
Impact of pre-adapted HIV transmission
Human leukocyte antigen class I (HLA)-restricted CD8+ T lymphocyte (CTL) responses are
crucial to HIV-1 control. Although HIV can evade these responses, the longer-term impact of …
crucial to HIV-1 control. Although HIV can evade these responses, the longer-term impact of …
Widespread impact of HLA restriction on immune control and escape pathways of HIV-1
The promiscuous presentation of epitopes by similar HLA class I alleles holds promise for a
universal T-cell-based HIV-1 vaccine. However, in some instances, cytotoxic T lymphocytes …
universal T-cell-based HIV-1 vaccine. However, in some instances, cytotoxic T lymphocytes …
Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection
Mutations that allow escape from CD8 T-cell responses are common in HIV-1 and may
attenuate pathogenesis by reducing viral fitness. While this has been demonstrated for …
attenuate pathogenesis by reducing viral fitness. While this has been demonstrated for …
Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1
ABSTRACT HLA class I-associated polymorphisms identified at the population level mark
viral sites under immune pressure by individual HLA alleles. As such, analysis of their …
viral sites under immune pressure by individual HLA alleles. As such, analysis of their …
HIV-1 Tat and viral latency: what we can learn from naturally occurring sequence variations
D Kamori, T Ueno - Frontiers in microbiology, 2017 - frontiersin.org
Despite the effective use of antiretroviral therapy, the remainder of a latently HIV-1-infected
reservoir mainly in the resting memory CD4+ T lymphocyte subset has provided a great …
reservoir mainly in the resting memory CD4+ T lymphocyte subset has provided a great …
HIV escape mutations occur preferentially at HLA-binding sites of CD8 T-cell epitopes
C Bronke, CAM Almeida, E McKinnon, SG Roberts… - Aids, 2013 - journals.lww.com
Objective: To define the relative frequencies of different mechanisms of viral escape. Design:
A population-based approach to examine the distribution of HIV polymorphism associated …
A population-based approach to examine the distribution of HIV polymorphism associated …