The human genetic epidemiology of COVID-19
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
Host genetic factors determining COVID-19 susceptibility and severity
TP Velavan, SR Pallerla, J Rüter, Y Augustin… - …, 2021 - thelancet.com
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2
(SARS-CoV-2) poses an unprecedented challenge to humanity. SARS-CoV-2 infections …
(SARS-CoV-2) poses an unprecedented challenge to humanity. SARS-CoV-2 infections …
COVID‐19 immunopathology: from acute diseases to chronic sequelae
The clinical manifestation of coronavirus disease 2019 (COVID‐19) mainly targets the lung
as a primary affected organ, which is also a critical site of immune cell activation by severe …
as a primary affected organ, which is also a critical site of immune cell activation by severe …
Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll‐like receptors dictates pathophysiology of COVID‐19 disease
MK Vakil, Y Mansoori, GRL Al‐Awsi… - Journal of Medical …, 2022 - Wiley Online Library
Innate and acquired immunity responses are crucial for viral infection elimination. However,
genetic variations in coding genes may exacerbate the inflammation or initiate devastating …
genetic variations in coding genes may exacerbate the inflammation or initiate devastating …
Tissue‐resident memory T cells and lung immunopathology
IS Cheon, YM Son, J Sun - Immunological Reviews, 2023 - Wiley Online Library
Rapid reaction to microbes invading mucosal tissues is key to protect the host against
disease. Respiratory tissue‐resident memory T (TRM) cells provide superior immunity …
disease. Respiratory tissue‐resident memory T (TRM) cells provide superior immunity …
Tissue immunity to SARS‐CoV‐2: role in protection and immunopathology
K Rybkina, J Davis‐Porada… - Immunological reviews, 2022 - Wiley Online Library
The SARS‐CoV‐2 pandemic has demonstrated the importance of studying antiviral
immunity within sites of infection to gain insights into mechanisms for immune protection and …
immunity within sites of infection to gain insights into mechanisms for immune protection and …
Delineating COVID-19 immunological features using single-cell RNA sequencing
Understanding the molecular mechanisms of coronavirus disease 2019 (COVID-19)
pathogenesis and immune response is vital for developing therapies. Single-cell RNA …
pathogenesis and immune response is vital for developing therapies. Single-cell RNA …
A multitrait locus regulates sarbecovirus pathogenesis
Infectious diseases have shaped the human population genetic structure, and genetic
variation influences the susceptibility to many viral diseases. However, a variety of …
variation influences the susceptibility to many viral diseases. However, a variety of …
[HTML][HTML] T cell control of SARS-CoV-2: When, which, and where?
MO Diniz, MK Maini, L Swadling - Seminars in Immunology, 2023 - Elsevier
Efficient immune protection against viruses such as SARS-CoV-2 requires the coordinated
activity of innate immunity, B and T cells. Accumulating data point to a critical role for T cells …
activity of innate immunity, B and T cells. Accumulating data point to a critical role for T cells …
The genetic and evolutionary determinants of COVID-19 susceptibility
G Kerner, L Quintana-Murci - European Journal of Human Genetics, 2022 - nature.com
Devastating pandemics, such as that due to COVID-19, can provide strong testimony to our
knowledge of the genetic and evolutionary determinants of infectious disease susceptibility …
knowledge of the genetic and evolutionary determinants of infectious disease susceptibility …