Treatment resistant depression: a multi-scale, systems biology approach
An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …
Even with an eventual recovery, many patients require a trial and error approach, as there …
Integrating endocannabinoid signaling and cannabinoids into the biology and treatment of posttraumatic stress disorder
Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …
Direct ventral hippocampal-prefrontal input is required for anxiety-related neural activity and behavior
The ventral hippocampus (vHPC), medial prefrontal cortex (mPFC), and basolateral
amygdala (BLA) are each required for the expression of anxiety-like behavior. Yet the role of …
amygdala (BLA) are each required for the expression of anxiety-like behavior. Yet the role of …
[HTML][HTML] Ghost interactions in MEG/EEG source space: A note of caution on inter-areal coupling measures
When combined with source modeling, magneto-(MEG) and electroencephalography (EEG)
can be used to study long-range interactions among cortical processes non-invasively …
can be used to study long-range interactions among cortical processes non-invasively …
Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task
Cross-frequency coupling supports the organization of brain rhythms and is present during a
range of cognitive functions. However, little is known about whether and how long-range …
range of cognitive functions. However, little is known about whether and how long-range …
Hippocampal-prefrontal interactions in cognition, behavior and psychiatric disease
T Sigurdsson, S Duvarci - Frontiers in systems neuroscience, 2016 - frontiersin.org
The hippocampus and prefrontal cortex (PFC) have long been known to play a central role
in various behavioral and cognitive functions. More recently, electrophysiological and …
in various behavioral and cognitive functions. More recently, electrophysiological and …
[HTML][HTML] Elevated anandamide, enhanced recall of fear extinction, and attenuated stress responses following inhibition of fatty acid amide hydrolase: a randomized …
Background Posttraumatic stress disorder, an area of large unmet medical needs, is
characterized by persistence of fear memories and maladaptive stress responses. In …
characterized by persistence of fear memories and maladaptive stress responses. In …
Widespread theta synchrony and high-frequency desynchronization underlies enhanced cognition
The idea that synchronous neural activity underlies cognition has driven an extensive body
of research in human and animal neuroscience. Yet, insufficient data on intracranial …
of research in human and animal neuroscience. Yet, insufficient data on intracranial …
Neuromodulation in circuits of aversive emotional learning
E Likhtik, JP Johansen - Nature neuroscience, 2019 - nature.com
Emotional learning and memory are functionally and dysfunctionally regulated by the
neuromodulatory state of the brain. While the role of excitatory and inhibitory neural circuits …
neuromodulatory state of the brain. While the role of excitatory and inhibitory neural circuits …
Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice
LM Mayo, A Asratian, J Lindé, L Holm, D Nätt… - Molecular …, 2020 - nature.com
Post-traumatic stress disorder (PTSD) is a common, debilitating condition with limited
treatment options. Extinction of fear memories through prolonged exposure therapy, the …
treatment options. Extinction of fear memories through prolonged exposure therapy, the …