A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Cells are the basic building blocks of organisms and each cell is unique. Single-cell RNA
sequencing has emerged as an indispensable tool to dissect the cellular heterogeneity and …

Single-cell transcriptomics is a versatile tool for exploring heterogeneous cell populations,
but as with all genomics experiments, batch effects can hamper data integration and …

Single-cell RNA-seq enables the quantitative characterization of cell types based on global
transcriptome profiles. We present single-cell consensus clustering (SC3), a user-friendly …

Single-cell RNA sequencing (scRNA-seq) has broad applications across biomedical
research. One of the key challenges is to ensure that only single, live cells are included in …

The major and essential objective of pre-implantation development is to establish embryonic
and extra-embryonic cell fates. To address when and how this fundamental process is …

Single-cell RNASeq (scRNASeq) has emerged as a powerful method for quantifying the
transcriptome of individual cells. However, the data from scRNASeq experiments is often …

Background A fundamental fact in biology states that genes do not operate in isolation, and
yet, methods that infer regulatory networks for single cell gene expression data have been …

The emergence of form and function during mammalian embryogenesis is a complex
process that involves multiple regulatory levels. The foundations of the body plan are laid …

Single-cell RNA sequencing (scRNA-seq) is a powerful technique to analyze the
transcriptomic heterogeneities at the single cell level. It is an important step for studying cell …